Cardiovascular research: Genetics of stroke risk and recovery
Profile of Jane Maguire

PROJECT LEAD  

Professor Jane Maguire

About

Professor Jane Maguire is current Deputy Head of School Research. Her program stems from 16 years of doctoral and postdoctoral research, collecting new clinical stroke data, pooling historical Australian data, and establishing the Australian Stroke Genetics Collaboration, to contribute 1200 carefully defined, ischaemic stroke cases with stroke risk and unique outcome data, included in many of the International Stroke Genetics Consortium research projects

Impact

This work has generated new knowledge fundamental to our current understanding of the underlying molecular biology of stroke risk and recovery. In addition, this program has led to the ongoing collection of 8,000 new stroke cases for Phase 2, with the aim to replicate the primary recovery meta-analysis results. 

To date, the creation of new molecular knowledge in the areas of stroke risk and recovery has had extensive international reach and informed 25 international projects conducted with colleagues in the UK, USA, Europe, and Australia, including three large international stroke databases since 2010. 

This knowledge has identified variants in unexpected mechanistic pathways that widen opportunities for prevention therapies and identified potential existing drug therapies to be repurposed for stroke targets.

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.