The capability to image cells at high resolution in their native environment has transformed our understanding of the spatial and temporal aspects of disease. However, inherent issues with the use of animal models and the increasing irrelevance of 2D cellular system is forcing the international community to look at alternate physiologically relevant systems.
Advanced micro-systems such as organ-on-a-chip are showing real promise in bridging the gap between in-vitro systems and the real human condition. They hold the promise of low cost, reproducible, physiologically relevant systems that will allow high throughput investigations into normal function and disease.
Organoids were recognised as Nature method of the year for 2017 and are a signficacnt step towards physiologically relevant systems Invitro system. However, at IBMD we want to extend the organoid concept to create a platform technology focused on truly integrated microphysiological systems.
At IBMD we build novel micro-physiological systems that integrate with:
- our existing and developing sensor technology,
- our advanced imaging platforms (including lattice light sheet and
- single cell characterisation capabilities
- advanced on chip control.
Such systems provide a novel way to study highly complex biological process in a extremely controlled manner with low sample input. We believe these will be critical for studying normal development, understanding disease processes, for drug discovery programs and in personalised medicine.
Figure 5. integration of IBMD's expertise towards human-on-a-chip and biologically relevant microsystems.
This capability is currently supported by the:
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