Facility hire

The Biologics Innovation Facility (BIF) offers Facility Hire Agreements to provide access to various graded clean rooms, within a GMP-simulated environment. Regarded as a sandbox environment, clients can recreate and develop their process in 3 x Grade D rooms, a Grade C or a Grade B room. Further, clients can utilise the range of equipment housed within the BIF or bring in their own equipment to establish their process.

The BIF offers a number of supporting services for large-scale projects, particularly with genetically modified organisms (GMOs).

  • Large scale PC2 certified – can produce GMO cultures up to 200L, with infrastructure in place to accommodate a 1000L bioreactor
  • Dedicated waste and decontamination plant – all liquid waste in the facility is treated on site, using dedicated decontamination tanks
  • Purified water system – three-steps of purification, reverse osmosis, ozone treatment and UV sterilisation. A 4000L tank is accessed through 8 outlets in the facility.
  • Temperature controlled units – four fixed and two standing units, connect to the facility mixing units and bioreactor, to provide a controlled temperature. Units are qualified from 4-60°C.
  • Air handling units – four separate units drive the facility clean rooms, and adjacent PC2 rooms. Each room has adjustable pressure differentials, including all airlocks between the corridor

Explore our equipment:

Upstream

  • ReadyToProcess Wave25 Bioreactor 
  • 200L Xcellerex XDR-200 single-use stirred-tank bioreactor 
  • Kuhner shaker incubator with CO2 
  • Ambr 250 Modular Bioreactor (2 modules) 
  • Eppendorf BioBlu
  • CO2 shaking incubators:
    • Kuhner ISF1-X
    • Eppendorf S41i
  • Nova Biomedical Stat Prime
  • Beckman Coulter Vi-CELL BLU

Downstream

  • ÄKTA Ready Gradient Single Use Chromatography systems 
  • ÄKTA ready flux Single Use Filtration systems 
  • ÄKTA flux 6 Small Scale tangential flow filtration systems 
  • Cytiva STAX Process Scale Chassis 

Buffer and Media preparation

  • Xcellerex XDM Single-Use Mixing System* XDM: 50L, 100L, 200L & 500L Product monitoring mixers 
  • XDUO-200T: 200L Product monitoring & control mixers 

Analytical:

  • Agilent 1260 HPLC
  • Perkin Elmer labchip
  • Charles River endosafe PTS endotoxin reader

Other:

  • Laftech 4 glove IPP-180 AC Isolator 
  • Particle monitoring
    • Lighthouse ActiveCount 100H
    • Lighthouse APEX Z50 Portable Particle Counter
  • Milliflex Oasis – Microbial testing 
  • Storage:
    • Three x 4°C refrigerator
    • One x -20°C freezer
    • Two x -80°C freezers
    • Warehouse and clean room stores
  • Watson Marlow – peristaltic pumps:
    • 630 mid-flow process pump
    • 2 x 530 process pumps 
  • Thermo Scientific Sorvall LYNX 6000
Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.