Sertraline for breathlessness

A randomised, double-blind, multi-site, parallel-arm, controlled trial to assess relief of refractory breathlessness comparing oral sertraline and placebo.

DOI	10.58084/hd69-tr47
Type of DOI	dataset
Publisher	Palliative Care Clinical Studies Collaborative (PaCCSC)
Creator(s)	Professor David Currow
Date made available	2024
Description of dataset	Data set includes: 223 participants were included in the intention-to-treat analysis (112 receiving sertraline and 111 receiving Placebo) treatment period over 28 days with follow-up fortnightly for 4 weeks when possible. demographic, medical history data, concurrent medications, and baseline clinical measures Primary outcome data measured by average breathlessness on 100mm visual analogue scale and safety and toxicity data measured using the NCI CTCAE V4.0. Other data for secondary analysis include Australia-modified Karnofsky Performance Status spirometry pulse oximetry resting respiratory rate pathology measures including full blood count, electrolyte function, renal function and serum sodium global impression of change blinded patient preference for symptomatic and net benefit MRC dyspnoea scale CRQ dyspnoae subscale EORTC- QLQ-15 and CQOLC measures of lifespace HADS breathlessness intensity and the degree to which it is unpleasant using VAS and four-point Likert scales dyspnoea scores for worst dyspnoea in the previous day measured on 0-10 NRS and a four point Likert scale severity ranking of dyspnoea target symptoms on Likert scales functional impairment scores on the MRC categorical scale Healthcare utilisation including number of inpatient admissions and days spent in hospital by level of dependency (low, medium, high) home care palliative care team visits general practitioner visits participant preference for where they prefer to be cared for given their current health state
Funding	Australian Government
Subject (ANZSRC category)	Cardiovascular edicine and haematology (respiratory disease)
ANZCTR reference	ACTRN12610000464066
Main trial page	PaCCSC clinical trials
Publications	Sertraline in symptomatic chronic breathlessness: a double-blind, randomised trial Sertraline or placebo in chronic breathlessness? Lessons from placebo research
Dataset access	Access can be requested via the Health Data Australia catalogue. Search for the ACTRN number in the catalogue to find datasets associated with these trials or email enquiries to hesanda@uts.edu.au.

Acknowledgement of Country

UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.