A randomised, double-blind multi-site parallel-arm, controlled trial to assess relief of refractory breathlessness comparing fixed doses of morphine and placebo.

DOI10.58084/7vg4-qk30
Type of DOIdataset
PublisherPalliative Care Clinical Studies Collaborative (PaCCSC)
Creator(s)Professor David Currow
Date made available2024
Description of dataset

Data set includes:

  • individual participant data for 299 consenting participants - a total of 284 participants were randomised (145 to Morphine, 139 to Placebo, and a further 74 participants to the oxycodone arm. The oxycodone arm was later dropped due to recruitment difficulties)
  • CSV files for screening and baseline, day 1 and day 7 outcome data, and 4 weeks of follow-up

Data is available for:

  • clinical investigations
  • demographic information
  • Functional assessment (AKPS and DES)
  • Dyspnoea descriptors
  • Breathlessness scores (VAS, Likert, and mMRC), EORTC QLQ-C15, and Respiratory Disease Questionnaire
  • Global Impression of Change
  • Carer Quality of Life
  • Life Space Assessment
  • Health Service Utilisation
  • Symptoms and Adverse Events.
     
FundingAustralian Government
Subject (ANZSRC category)Cardiovascular medicine and haematology (respiratory diseases)
ANZCTR reference 
Main trial pagePaCCSC clinical trials
Publications

Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial (https://doi.org/10.1136/thoraxjnl-2019-213681).

Controlled-Release Oxycodone vs. Placebo in the Treatment of Chronic Breathlessness-A Multisite Randomized Placebo Controlled Trial (10.1016/j.jpainsymman.2019.10.017).

Opioids for breathlessness: a narrative review (https://doi.org/10.1136/bmjspcare-2020-002314).

Dataset accessAccess can be requested via the Health Data Australia catalogue. Search for the ACTRN number in the catalogue to find datasets associated with these trials or email enquiries to hesanda@uts.edu.au.