Cancer Biology Group

About us

My primary research interests are in the investigation of the genetic and molecular basis of colorectal and other cancers with the ultimate aim of developing diagnostic/prognostic biomarkers and future novel therapies for cancer. My current research is focused on determining how alterations in the expression and/or function of an important tumour suppressor gene, PTEN, contributes to the development and/or progression of cancer. 

More specifically, current research projects examine: (1) the effect of mutations of the PTEN gene on the function of PTEN and the consequent cellular functional effects brought about by such mutations and (2) investigating the role of a pseudogene of PTEN (PTENP1) in the regulation PTEN expression and cellular abundance through competition for microRNA binding and direct transcriptional regulation. I also collaborate with other researchers at UTS and externally.

Collaborations

Within UTS

Professor Ann Simpson (diabetes research group)
Associate Professor Sara Lal, Neuroscience Research Unit
Associate Professor Bronwyn O’Brien

External

Institute of Haematology, Royal Prince Alfred Hospital
The ANZAC Research Institute and University of Sydney
Children’s Medical Research Institute (CIMR)
Medical University of South Carolina, USA.
Kolling Institute of Medical Research (KIMR)