Designer drugs are constantly evolving, which means the ability to quickly and accurately detect them must follow suit.
You’ve likely seen it depicted in a medical drama; an ambulance pulls up, the paramedic kneels beside an unresponsive person to look for clues and vital signs, trying to decipher what’s happened. But when it comes to synthetic drugs and overdoses, the answer isn’t always clear – especially when what someone’s taken isn’t what they think.
But what if there was a way to quickly and accurately detect synthetic drugs? Thanks to new research, there is.
Fast and accurate detection
During her PhD, UTS forensic scientist Dr Morgan Alonzo developed the first rapid test for synthetic cathinones – better known as bath salts.
These synthetic cathinones are so similar to amphetamines, they were previously exceptionally difficult to detect.
“[They] are a large class of new psychoactive substances with a structure very similar to amphetamines – just one oxygen atom different – but that makes all the difference in terms of detection,” Alonzo says.
Not only is the test fast – it’s portable and can be done anywhere. The new testing method is not unlike the COVID rapid tests we now know so well. A small sample of the drug is added to a test tube. Next, a chemical compound is added, designed to create a chemical reaction. If the substance being tested for is present, the solution will change colour.
This project, done in conjunction with German company ESATest GmbH and with support from the Global Connections Fund, laid the groundwork for future iterations.
And the scope for future drug testing is massive.
Cocaine, for example, is often ‘cut’ with other substances when sold. While a user might believe they’re taking pure cocaine, there’s a rise in cocaine being mixed with new psychoactive substances (NPSs).
These NPSs are illicit lab-made chemical compounds. In other words, they are lab-made drugs designed to mimic the effects of common drugs such as cannabis, amphetamines, LSD and heroin.
New drug tests for synthetic drugs
If the substance being tested for is present, the solution will change colour once a chemical compound is added.
Our test was able to give a quick indication, within a minute or two, that you had a cathinone present in a sample. Because the test was quite successful, we then went on to look at what other synthetic drugs we could detect using colour tests.
Harm reduction
Alonzo, together with Professor of Forensic Toxicology Shanlin Fu, have now patented two more rapid tests: one for NBOMes, which are powerful hallucinogens similar to LSD; and one to test for fentanyl analogues – synthetic opioids. They’ve also developed a test for piperazine derivatives (a common adulterant for club drugs like MDMA), along with a new version of the Scott test – the current rapid test for cocaine – in the pipeline.
And they’re not stopping there. They plan to develop an easy-to-use, all-in-one NPS rapid test.
It’s the lack of data on NPSs that makes this research so groundbreaking. The rapid evolution of these drugs means there’s no database for their chemical structure.
Professor Fu explains that until the team developed these tests, "[NPSs] often slipped through the law enforcement net”.
These new tests will give law enforcement agencies and customs services another tool in their fight against illicit drug importation.
“The illicit drug industry is always trying to stay a step ahead and circumvent drug laws, so the need for effective drug testing methods has become increasingly urgent," says Professor Fu.
It's difficult to quantify the potential impact of these rapid tests. The results can empower doctors and paramedics with life-saving knowledge in emergencies. And in settings employing pill testing, the information these tests provide can help users make better informed decisions and avoid potential risks.