On-the-spot coronavirus test within spitting distance
A COVID-19 test that will provide results within minutes, easing the way for borders to reopen, is set to be manufactured in Australia for Australian use.
So why this virus is so contingent because our body is very slow in response to the infection. It typically takes a week before our bodies start to show the symptoms. The goal for us is to use a nanophotonics approach to detect this window, okay, before the symptoms but they're already infectious. The test mainly based on the nanoprobe technologies are these probes they are super bright and their signal can be sensitive to the single molecular level. After adding the saliva on the strip sensor we can read the optical signal by using a meter so that the proteins of virus can be detected. Unlike current conventional tests – they take the swab and takes several days to get your results - our test can deliver that result within minutes so we can detect asymptomatic and symptomatic people around … so, for, example in airports if you decided to travel you can get tested within minutes and if you're negative you can continue with your planned travel and enjoy your vacation. It's Australian innovation and together with Australian company Alcolizer we can create rapid tests for COVID-19 here in Australia.
Mass testing that is fast, non-invasive and able to identify cases before people show symptoms holds the key to boosting COVID-19 detection, improving contact tracing and managing disease outbreaks.
In an Australian first, UTS scientists have used novel optical technology to design a highly sensitive saliva test for the SARS-CoV-2 virus antigens, or viral protein fragments. The test can deliver a positive result in under 15 minutes.
The rapid antigen test collects saliva in a cartridge placed in an existing hand-held device, first developed by Perth company Alcolizer for illicit drug testing.
Customised iStrip technology measures the viral load in the saliva sample, even at very low levels, and displays the result on the instrument’s small screen. The device has GPS location technology and integration to cloud reporting tools to assist with contact tracing.
The test bypasses the time-consuming molecular amplification currently in use. With the quick turnaround of results and a cost of less than $25 per test, it would allow testing rates to increase.
Professor Dayong Jin, left, and his UTS team, Dr Jiajia Zhou, Associate Professor Olga Shimoni and Associate Professor Majid Warkiani. Photo by Toby Burrows
The iStrip technology is based on the pioneering work of UTS Professor Dayong Jin in using nanophotonic probes for disease diagnostics. This iStrip is sensitive enough to detect the presence of as little as a trillionth of a gram of SARS-CoV-2 viral protein.
In collaboration with long-standing industry partner Alcolizer, Professor Jin and his team have developed a prototype, with laboratory trials on live virus expected to begin within two months. Manufacture of iStrips and testing instruments would take place in Australia, at Alcolizer’s fully automated robotic facility in Balcatta, Western Australia.
Development of the new medical device, called the Virulizer, has received a boost with Alcolizer receiving a federal government grant of $742,000.
Almost all testing for COVID-19 in Australia – more than 8.1 million tests to date – has used the gold standard PCR (polymerase chain reaction) test, where samples are analysed in a laboratory over several hours. However, with the global pandemic not yet at its peak, rapid antigen tests are attracting increasing attention.
Short of a vaccine, our best hope for returning to normal life lies in a fast, highly sensitive and accurate testing regime.
Professor Dayong Jin
Professor Jin said his team’s goal is detection of the presence of SARS-CoV-2 viral protein when a person has yet to show symptoms but is highly infectious.
“A person with COVID-19 may be contagious 72 hours before starting to show symptoms. With the sensitivity of our optical technology, we aim to identify the viral protein in saliva from asymptomatic but already infectious patients. This would allow for much more effective contact tracing and rapid discovery of pockets of disease before it is transmitted to others.
“Currently, a PCR swab from the nose or throat is being processed in the lab over a day or more, meaning valuable time is lost in finding, testing and isolating those known contacts of people who are infected with the virus.”
The test could be used in airports, hospitals, nursing homes and workplaces. The health, economic and social benefits are clear.
Roger Hunt, Alcolizer
Professor Jin said currently available antigen tests are authorised for use only within the first seven days after the onset of symptoms.
“They are not sensitive enough to effectively screen people who are showing no signs of illness. They also produce a number of false negative results,” he said.
“Short of a vaccine, our best hope for containing community transmission and returning to some sort of normal life lies in a fast, highly sensitive and accurate testing regime. We believe our technology will help to realise that ambition.”
Alcolizer general manager Roger Hunt said: “This will be a quantum step in the community’s ability to identify COVID-19 on the front line. Once commercialised, this test will fight the disease, generate significant employment, and greatly enhance export opportunities.
This is a great example of how an Australian SME, through collaboration with a university, is able to boost its manufacturing capability and accelerate diversification of the business.
David Chuter, Innovative Manufacturing CRC
“A vaccine for COVID-19 is not guaranteed, and therefore a test like this is vital for reopening our borders and the economy. The test could be used in airports, hospitals, nursing homes and workplaces. The health, economic and social benefits are clear.”
This project also received financial support from Innovative Manufacturing CRC (IMCRC).
“This is a great example of how an Australian SME, through collaboration with a university, is able to boost its manufacturing capability and accelerate diversification of the business into ‘new manufacturing’ opportunities and value chains,” David Chuter, CEO and Managing Director, said.
This story was updated on 10 June 2021`, after the announcement by Federal Industry Minister Christian Porter of $3.7 million in manufacturing grants, which included Alcolizer.
Professor Jin’s research team includes Drs Leo Zhang, Jiajia Zhou, Shihui Wen, Meysam Rezaeishahmirzadi, Jiayan Liao, Riikka Arppe-Tabbara and Amani Alghalayini, Associate Professor Olga Shimoni, Associate Professor Majid Warkiani and Professor Stella Valenzuela, at the UTS Institute for Biomedical Materials & Devices, the ARC Research Hub for Integrated Device for End-user Analysis at Low-levels (IDEAL) and the DISER Australia-China Joint Research Centre for Point of Care Testing.
