Adhikari, S, Mahmud, MAP, Moon, E & Timms, W 2025, 'Assessing the environmental benefits of biochar application in agriculture: Insights from lifecycle assessment'.
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Organic waste-derived biochar has been proven to have a significant potential for soil improvement, with recent results from this group showing evidence for improved water holding capacity, carbon stability and exchangeable cations. However, to contextualise these benefits it is important to consider environmental impacts during each stage of life cycle for the product.In this study, a cradle-to-gate life cycle assessment (LCA) was performed, comparing a common use for garden organics (composting) to two alternative scenarios. One involved converting over-sized compost screenings (otherwise considered waste) to biochar as a supplementary product from the process, and the other involved converting garden organics directly to biochar as an alternative product.LCA was conducted using ReCiPe2016 impact assessment method in OpenLCA software. Data for assessment were collected from the participating industries and Ecoinvent database. Sensitivity analysis considering different transport distances was carried out and finally an optimum transport distance with the lowest environmental impacts was recommended. Additionally, physico-chemical characterisation and carbon stability assessment were conducted to provide a comprehensive idea about the overall benefits of organic waste-derived biochar for soil and climate.Our results revealed that global warming was increased from 675 kgCO2eq during composting of garden waste to 1017 kgCO2eq where over-sized screenings of compost is converted to biochar as a value-added product. Direct conversion of organic waste to biochar showed reduced global warming impact of 428 kgCO2eq compared to the previous two scenarios. Among 16 environmental impact indicators studied, the magnitude of 10 impact indicators increased with transport distance, while the remaining six indicators were not influenced by transport distance.Soil application of biochar from organic waste has multiple co-benefits, that can be short and/or long t...
Afrose, D, Alfonso-Sánchez, S & McClements, L 2025, 'Targeting oxidative stress in preeclampsia', Hypertension in Pregnancy, vol. 44, no. 1.
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Angeloski, A, Galaviz, P, Mole, RA, Piltz, RO, McDonagh, AM, Ennis, C & Appadoo, D 2025, 'Manipulating a Thermosalient Crystal Using Selective Deuteration', Journal of the American Chemical Society, vol. 147, no. 9, pp. 8032-8047.
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Armbrecht, L, Focardi, A, Lawler, K-A, O’Brien, P, Leventer, A, Noble, T, Opdyke, B, Duffy, M, Evangelinos, D, George, SC, Lieser, J, López-Quirós, A, Post, A, Ostrowski, M, Paulsen, I & Armand, L 2025, 'From the Surface Ocean to the Seafloor: Linking Modern and Paleo-Genetics at the Sabrina Coast, East Antarctica (IN2017_V01)'.
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With ongoing climate change, research into the biological changes occurring in particularly vulnerable ecosystems, such as Antarctica, is critical. The Totten Glacier region, Sabrina Coast, is currently experiencing some of the highest rates of thinning across all East Antarctica. An assessment of the microscopic organisms supporting the ecosystem of the marginal sea-ice zone over the continental rise is important, yet there is a lack of knowledge about the diversity and distribution of these organisms throughout the water column, and their occurrence and/or preservation in the underlying sediments. Here, we provide a taxonomic overview of the modern and ancient marine bacterial and eukaryotic communities of the Totten Glacier region, using a combination of 16S and 18S rRNA gene amplicon sequencing (modern DNA) and shotgun metagenomics (sedimentary ancient DNA, sedaDNA). Our data show considerable differences between eukaryote and bacterial signals in the water column versus the sediments. Proteobacteria and diatoms dominate the bacterial and eukaryote composition in the upper water column, while diatoms, dinoflagellates, and haptophytes notably decrease in relative abundance with increasing water depth. Little diatom sedaDNA was recovered from the sediments. Instead, sedaDNA was dominated by Proteobacteria and Retaria. We compare the diatom microfossil and sedaDNA record and link the weak preservation of diatom sedaDNA to DNA degradation while sinking through the water column to the seafloor. This study provides the first assessment of DNA transfer from ocean waters to sediments and an overview of the microscopic communities occurring in the climatically important Totten Glacier region. Such knowledge is important when reconstructing past ecosystems using the emerging sedaDNA approach as a new paleo-proxy, and the interpretation of biological changes in response to Antarctic ice sheet advances and retreats.
Ashique, S, Mishra, N, Garg, A, Garg, S, Farid, A, Rai, S, Gupta, G, Dua, K, Paudel, KR & Taghizadeh-Hesary, F 2025, 'A Critical Review on the Long-Term COVID-19 Impacts on Patients With Diabetes', The American Journal of Medicine, vol. 138, no. 2, pp. 308-329.
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Awad, W, Mayall, JR, Xu, W, Johansen, MD, Patton, T, Lim, XY, Galvao, I, Howson, LJ, Brown, AC, Haw, TJ, Donovan, C, Das, S, Albers, GJ, Pai, T-Y, Hortle, E, Gillis, CM, Hansbro, NG, Horvat, JC, Liu, L, Mak, JYW, McCluskey, J, Fairlie, DP, Corbett, AJ, Hansbro, PM & Rossjohn, J 2025, 'Cigarette smoke components modulate the MR1–MAIT axis', Journal of Experimental Medicine, vol. 222, no. 2.
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Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function. MR1 is a ubiquitous molecule that presents bacterial metabolites to MAIT cells, which are highly abundant in the lungs. Using in silico, cellular, and biochemical approaches, we identified components of CS that bind MR1 and impact MR1 cell surface expression. Compounds, including nicotinaldehyde, phenylpropanoid, and benzaldehyde-related scaffolds, bound within the A′ pocket of MR1. CS inhibited MAIT cell activation, ex vivo, via TCR-dependent and TCR-independent mechanisms. Chronic CS exposure altered MAIT cell phenotype and function and attenuated MAIT cell responses to influenza A virus infection in vivo. MR1-deficient mice were partially protected from the development of chronic obstructive pulmonary disease (COPD) features that were associated with CS exposure. Thus, CS can impair MAIT cell function by diverse mechanisms, and potentially contribute to infection susceptibility and disease exacerbations.
Bai, X, Zhang, Y, Zhao, H, Zi, Y, Xu, Z, Huang, A, Cun, Y, Liu, Y, Song, Z, Qiu, J, Liao, J & Yang, Z 2025, 'Flexible X‐Ray Detector for Cumulative Dose Monitoring Through Reversible Photochromism and Luminescence Modulation', Advanced Science, vol. 12, no. 6.
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AbstractThis study presents a multi‐mode X‐ray detection and imaging strategy by integrating photochromism, photoluminescence, and radioluminescence into Tb3+‐doped CaAl2Si2O8. CaAl2Si2O8: Tb3+ exhibits stable radioluminescence, oxygen vacancy‐related photochromism, and photoluminescence modulation, all of which showed a linear relationship with X‐ray exposure. This multi‐mode response enables high‐quality imaging and detection in both bright and dark conditions, facilitating time‐dependent cumulative X‐ray radiation dose assessments. Reversible color and luminescence changes are achieved through cyclic tests involving alternating X‐ray and 473 nm laser irradiation. The PDMS CaAl2Si2O8: Tb3+ ink and flexible film demonstrate high suitability for wearable X‐ray detection devices and imaging of irregular objects, offering an innovative approach to X‐ray detection and imaging.
Baumgart, A, Clarke, RJ, Cranfield, CG, Zerlotti, R & Buoninsegni, FT 2025, 'BPS2025 - Membrane binding of hydrophobic ions: Dipole potential revisited', Biophysical Journal, vol. 124, no. 3, pp. 92a-92a.
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Bellotto, C, Fowler, AM & Booth, DJ 2025, 'Overwintering performance of three juvenile temperate estuarine fishes', Journal of Experimental Marine Biology and Ecology, vol. 584, pp. 152087-152087.
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Beltrán, I, Vila-Pouca, C, Loiseleur, R, Webb, JK, Herculano-Houzel, S & Whiting, MJ 2025, 'Effect of elevated incubation temperatures on learning and brain anatomy of hatchling and juvenile lizards', Journal of Comparative Physiology B, vol. 195, no. 1, pp. 67-79.
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Berezowski, V, Taoum, K, Wang, J, Birch, P, Roux, C & Huo, H 2025, 'Investigating identity crime and misuse in Australia: the role of prevention technologies and the likelihood of victimisation', Journal of Criminological Research, Policy and Practice, vol. 11, no. 1, pp. 50-63.
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PurposeThis study examines identity theft as a significant and growing issue in Australia, not only due to its financial impact but also because of the emotional, psychological, and physical harm it causes, making it a public health concern. This study aims to analyse the results of the 2019 Australian Institute of Criminology (AIC) survey to identify factors associated with an increased likelihood of identity theft victimisation.Design/methodology/approachThis study involved a detailed analysis of the 2019 AIC survey, which had 9,968 respondents from a sample of 10,000. The research focused on whether respondents had ever been victimised by identity theft and analysed various characteristics, including demographics (gender, age, Indigenous status, education), income, computer usage, and preventive technology use, as potential indicators of future victimisation. Univariate analyses (chi-squared test and two-sample t-test) were used to assess individual associations, whereas a multivariate analysis (logistic regression) identified significant predictors of victimisation.FindingsThe univariate analyses indicated that all sub-variables were individually associated with identity theft victimisation. However, the multivariate analysis revealed that only identifying as Aboriginal and Torres Strait Islander, having an income between $18,201 and $37,000, and using multiple preventive technologies were significant predictors of victimisation. The unexpected finding that increased preventive technology use correlates with a higher risk of victimisation contradicts the survey’s suggestion that victims adopt more careful behaviour post-victimisation....
Bergin, R, Peters, S, Mitrovic, S & Bishop, DP 2025, 'Simultaneous Multiclass Analysis of Cyanotoxins in Cyanobacterial Samples Using Hydrophilic Interaction Liquid Chromatography‐Tandem Mass Spectrometry', Journal of Separation Science, vol. 48, no. 3.
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ABSTRACTThe proliferation of cyanobacteria can result in algal blooms, which may cause environmental and biological harm due to the production and release of secondary metabolites, or cyanotoxins, into the affected waterway. Cyanobacteria can produce multiple classes of cyanotoxins; therefore, to understand the full toxic load of algal blooms, it is necessary to perform analyses that quantify each class. These classes are generally monitored individually due to the challenges associated with the differing physicochemical properties of the cyanotoxins. Hydrophilic interaction liquid chromatography (HILIC) is a form of chromatography capable of retaining multiple classes of cyanotoxins that differ in physicochemical properties. Here an HILIC‐MS/MS method was developed and validated to detect 3 microcystins, 11 saxitoxins, and 2 anatoxins. The chromatographic conditions were optimized to allow for the separation of multiple pairs of saxitoxin epimers, and in‐source fragmentation in the MS interface was used to develop unique MRMs between the pairs. The method was validated and had low limits of detection (LODs, between 0.00770 and 9.75 µg L−1) and limits of quantification (LOQs, between 0.0257 and 32.5 µg L−1) for all compounds. All analytes exhibited good linearity (R2 values ≥ 0.991) and low percentage relative standard deviations for retention time (0%–1.74%) and peak area (4.54%–27.6%), with spiked recoveries ranging from 75.6% to 117% for all compounds. A multiclass sample preparation method to extract the three classes of analytes from cyanobacterial samples was developed and validated, with 80:20 acetonitrile:water and 0.1% formic acid as the optimal extraction solvent. The newly developed sample preparation and analysis methods were applied to cultured cyanobacteria and field samples, with microcystins and saxitoxins detected. ...
Bhattacharya, K, Bhattacharjee, A, Chakraborty, M, Das, D & Paudel, KR 2025, 'From Antipsychotic to Neuroprotective: Computational Repurposing of Fluspirilene as a Potential PDE5 Inhibitor for Alzheimer's Disease', Journal of Computational Chemistry, vol. 46, no. 2.
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ABSTRACTPhosphodiesterase 5 (PDE5) inhibitors have shown great potential in treating Alzheimer's disease by improving memory and cognitive function. In this study, we evaluated fluspirilene, a drug commonly used to treat schizophrenia, as a potential PDE5 inhibitor using computational methods. Molecular docking revealed that fluspirilene binds strongly to PDE5, supported by hydrophobic and aromatic interactions. Molecular dynamics simulations confirmed that the fluspirilene–PDE5 complex is stable and maintains its structural integrity over time. Binding energy calculations further highlighted favorable interactions, indicating that the drug forms a strong and stable bond with PDE5. Additional analyses, including studies of protein dynamics and energy landscape mapping, revealed how the drug interacts dynamically with PDE5, adapting to different conformations and maintaining stability. These findings suggest that fluspirilene may modulate PDE5 activity, potentially offering therapeutic benefits for Alzheimer's disease. This study provides strong evidence for repurposing fluspirilene as a treatment for Alzheimer's and lays the foundation for further experimental and clinical investigations.
Birla, D, Khandale, N, Bashir, B, ShahbazAlam, M, Vishwas, S, Gupta, G, Dureja, H, Kumbhar, PS, Disouza, J, Patravale, V, Veiga, F, Paiva-Santos, AC, Pillappan, R, Paudel, KR, Goh, BH, Singh, M, Dua, K & Singh, SK 2025, 'Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices', Drug Delivery and Translational Research, vol. 15, no. 3, pp. 798-830.
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Bokshi, B, Chen, H & Ung, AT 2025, 'Antidiabetic property of fractions and pure compounds from Andrographis paniculata', Natural Product Research, vol. 39, no. 5, pp. 1101-1110.
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Brockbals, L, Ueland, M, Fu, S & Padula, MP 2025, 'Development and thorough evaluation of a multi-omics sample preparation workflow for comprehensive LC-MS/MS-based metabolomics, lipidomics and proteomics datasets', Talanta, vol. 286, pp. 127442-127442.
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Brown, AC, Carroll, OR, Mayall, JR, Zounemat-Kermani, N, Vinzenz, SLE, Gomez, HM, Mills, EF, Kim, RY, Donovan, C, Baines, KJ, Williams, EJ, Berthon, BS, Wynne, K, Scott, HA, Pinkerton, JW, Guo, Y, Hansbro, PM, Foster, PS, Wark, PAB, Dahlen, S-E, Adcock, IM, Wood, LG & Horvat, JC 2025, 'Female sex hormones and the oral contraceptive pill modulate asthma severity through GLUT-1', Mucosal Immunology.
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Button, C, Poddar, N, Lacassagne, T, Pernice, M, Gupta, V, Aditya, L, Kuzhiumparambil, U & Ralph, PJ 2025, 'Rheological characterization and modeling of freshwater and marine microalgae and cyanobacteria mixed cultures', Algal Research, vol. 88, pp. 103988-103988.
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Buzova, D, Petrilli, LL, Frohlich, J, Tsoneva, DK, Bianco, SD, Braghini, MR, Alisi, A, Mastronuzzi, A, Cerveny, J, Mazza, T, Vinci, M & Vinciguerra, M 2025, 'Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma', Molecular Diagnosis & Therapy, vol. 29, no. 1, pp. 129-141.
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Çakan, A, Cholsuk, C, Gale, A, Kianinia, M, Paçal, S, Ateş, S, Aharonovich, I, Toth, M & Vogl, T 2025, 'Quantum Optics Applications of Hexagonal Boron Nitride Defects', Advanced Optical Materials, vol. 13, no. 7.
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AbstractHexagonal boron nitride (hBN) has emerged as a compelling platform for both classical and quantum technologies. In particular, the past decade has witnessed a surge of novel ideas and developments, which may be overwhelming for newcomers to the field. This review provides an overview of the fundamental concepts and key applications of hBN, including quantum sensing, quantum key distribution, quantum computing, and quantum memory. Additionally, critical experimental and theoretical advances that have expanded the capabilities of hBN are highlighted, in a cohesive and accessible manner. The objective is to equip readers with a comprehensive understanding of the diverse applications of hBN, and provide insights into ongoing research efforts.
Capon, SJ, Steinfeld, CM, Pittock, J, Moggridge, BJ, Ward, A, Baumgartner, LJ, Sheldon, F, Ward, M & Medaris, DL 2025, 'Repairing Australia’s inland river and groundwater systems: nine priority actions, benefits and the finance gap', Marine and Freshwater Research, vol. 76, no. 4, pp. NULL-NULL.
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Chambers, GA, Geering, ADW, Bogema, DR, Holford, P, Vidalakis, G & Donovan, NJ 2025, 'Characterisation of the genetic diversity of citrus viroid VII using amplicon sequencing', Archives of Virology, vol. 170, no. 1.
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Chen, H & Lim, CED 2025, 'Advancing global healthcare: Methodological innovations for integrating Chinese medicine', Journal of Traditional Chinese Medical Sciences.
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Chen, L, A. Hoefel, G, Pathinayake, PS, Reid, A, Pillar, AL, Kelly, C, Tan, H, Ali, A, Kim, RY, Hansbro, PM, Brody, SL, Foster, PS, Horvat, JC, Riveros, C, Awatade, N, Wark, PAB & Kaiko, GE 2025, 'Inflammation‐induced loss of CFTR‐expressing airway ionocytes in non‐eosinophilic asthma', Respirology, vol. 30, no. 1, pp. 25-40.
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AbstractBackground and ObjectiveSevere asthma is a heterogeneous disease with subtype classification according to dominant airway infiltrates, including eosinophilic (Type 2 high), or non‐eosinophilic asthma. Non‐eosinophilic asthma is further divided into paucigranulocytic or neutrophilic asthma characterized by elevated neutrophils, and mixed Type 1 and Type 17 cytokines in the airways. Severe non‐eosinophilic asthma has few effective treatments and many patients do not qualify for biologic therapies. The cystic fibrosis transmembrane conductance regulator (CFTR) is dysregulated in multiple respiratory diseases including cystic fibrosis and chronic obstructive pulmonary disease and has proven a valuable therapeutic target. We hypothesized that the CFTR may also play a role in non‐eosinophilic asthma.MethodsPatient‐derived human bronchial epithelial cells (hBECs) were isolated and differentiated at the air‐liquid interface. Single cell RNA‐sequencing (scRNAseq) was used to identify epithelial cell subtypes and transcriptional activity. Ion transport was investigated with Ussing chambers and immunofluorescent quantification of ionocyte abundance in human airway epithelial cells and murine models of asthma.ResultsWe identified that hBECs from patients with non‐eosinophilic asthma had reduced CFTR function, and did not differentiate into CFTR‐expressing ionocytes compared to those from eosinophilic asthma or healthy donors. Similarly, ionocytes were also diminished in the airways of a murine model of neutrophilic‐dominant but not eosinophilic asthma. Treatment of hBECs from healthy donors with a neutrophilic asthma‐like inflammatory cytokine mixture led to a reduction in ionocytes.ConclusionInflammation...
Chhor, M, Barman, S, Heidari, F, Bottomley, AL, Robson, T, McGrath, K & McClements, L 2025, 'FK506 binding protein like, FKBPL, as a novel therapeutic target in 2D and 3D bioprinted, models of cardiac fibrosis', Bioprinting, vol. 47, pp. e00397-e00397.
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Chowdhury, T, Paul, DK, Rahaman, MR, Ton-That, C & Rahman, MA 2025, 'Temperature-dependent broadening of spectral lineshapes and kinetics of luminescence centers in monoclinic gallium oxide nanowires', Journal of Alloys and Compounds, vol. 1010, pp. 177609-177609.
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Dawson, BM, Johnston, NP, Cerato, S, Rowbottom, R, Spurr, C, Davis, A & Rader, R 2025, 'Adding non-floral resources increases wild insect abundance but not yield in Australian hybrid carrot crops', Basic and Applied Ecology, vol. 84, pp. 21-28.
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Demyanenko, Y, Sui, X, Giltrap, AM, Davis, BG, Küster, B & Mohammed, S 2025, 'Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine', Molecular & Cellular Proteomics, pp. 100948-100948.
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Dhiman, B, Yadav, M, Dhiman, A & Satija, S 2025, 'Novel analytical approach for baclofen quantification in rodent plasma', Biomedical Chromatography, vol. 39, no. 1.
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AbstractA simple, accurate, and robust reverse‐phase high‐performance liquid chromatography (RP‐HPLC) method was developed and validated for the quantification of Baclofen in rat plasma. The method demonstrated high degree of linearity (r2 = 0.9936) across a concentration range of 10–50 μg/mL. Precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), and robustness were evaluated according to ICH guidelines. The LOD and LOQ were found to be 0.076197 and 0.23090 μg/mL, respectively. This method provides an efficient approach for Baclofen quantification in plasma, making it suitable for pharmacokinetic and bioavailability studies. The novelty of this study lies in its optimization for routine use in laboratories, ensuring reproducibility with minimal variations across different conditions and analysts.
Ding, L, Zhong, Z, Chen, C, Liu, B, Chen, Z, Zhang, L, Mao, J, Zhang, M, Su, QP & Cheng, F 2025, 'Advances in multiplexed photoelectrochemical sensors for multiple components', Chemical Engineering Journal, vol. 505, pp. 159319-159319.
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D'Silva, A, Barnes, J, Djafar, J, Bhattacharya, K, Yan, J, Mohammad, S, Bandodkar, S, Johnson, A, Tchan, M, Miteff, C, Elvidge, KL, Dale, RC & Farrar, M 2025, 'Characterizing circulating biomarkers for childhood dementia disorders: A scoping review of clinical trials', Neurotherapeutics, vol. 22, no. 2, pp. e00546-e00546.
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Ehrnst, Y, Alijani, H, Bentley, C, Sherrell, PC, Murdoch, BJ, Yeo, LY & Rezk, AR 2025, 'UNLEASH: Ultralow Nanocluster Loading of Pt via Electro‐Acoustic Seasoning of Heterocatalysts', Advanced Materials, vol. 37, no. 3.
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AbstractThe shift toward sustainable energy has fueled the development of advanced electrocatalysts to enable green fuel production and chemical synthesis. To date, no material outperforms Pt‐group catalysts for key electrocatalytic reactions, necessitating advanced catalysts that minimize use of these rare and expensive constituents (i.e., Pt) to reduce cost without sacrificing activity. Whilst a myriad of routes involving co‐synthesis of Pt with other elements have been reported, the Pt is often buried within the bulk of the composite, rendering a large proportion of it inaccessible to the interfacial electrocatalytic reaction. Surface decoration of Pt on arbitrary substrates is therefore desirable to maximize catalytic activity; nevertheless, Pt electrodeposition suffers from clustering and ripening effects that result in large () aggregates that hinder electrocatalytic activity. Herein, an unconventional synthesis method is reported that utilizes high‐frequency (10 MHz) acoustic waves to electrochemically ‘season’ a gold working electrode with an ultralow loading of Pt nanoclusters. The UNLEASH platform is shown to facilitate high‐density dispersion of nanometer‐order clusters at the bimetallic interface to enable superior atomic utilization of Pt. This is exemplified by its utility for methanol oxidation reaction (MOR), wherein a mass activity of 5.28 A is obtained, outperforming all other Au/Pt bimetallic electrocatalysts reported to date.
Engdahl, J, Scammell, H, Efimkin, D & Sushkov, O 2025, 'Excitons in atomically thin transition metal dichalcogenides in electric and magnetic fields', Physical Review B: Covering condensed matter and materials physics, vol. 111, no. 3.
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Feng, M, Padula, MP, Asaad, SA, Bai, X, Cranfield, C, Town, SEL, Saad, S, Oliver, BG, George, J & Chen, H 2025, 'Prolonged exposure to low-dose traffic-derived PM2.5 causes fatty liver disorder in mice', Journal of Environmental Sciences.
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Focardi, A, Seymour, JR & Raina, J-B 2025, 'Overlooked tripartite microbial interactions influencing chemical cycling in the ocean', Trends in Microbiology, vol. 33, no. 3, pp. 253-254.
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Ganesan, K, Ghorbanpour, S, Kendall, W, Broome, ST, Gladding, JM, Dhungana, A, Abiero, AR, Mahmoudi, M, Castorina, A, Kendig, MD, Becchi, S, Valova, V, Cole, L & Bradfield, LA 2025, 'Hippocampal neuroinflammation induced by lipopolysaccharide causes sex-specific disruptions in action selection, food approach memories, and neuronal activation', Brain, Behavior, and Immunity, vol. 124, pp. 9-27.
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Giglio, VJ, Adelir‐Alves, J, Balzaretti Merino, N, Bravo‐Olivas, ML, Camp, EF, Casoli, E, Chávez‐Dagostino, RM, Ferretti, E, Fraser, D, Grillo, AC, Jiménez‐Guiérrez, S, Leite, KL, Lucrezi, S, Luiz, OJ, Luna‐Pérez, B, McBride, J, Milanese, M, Moity, N, Pinheiro, JV, Renfro, B, Roche, R, Saliba, BM, Sara, A, Schiavetti, A, Toso, Y, Valle‐Pérez, C & Ferreira, CEL 2025, 'DiverReef: A global database of the behavior of recreational divers and their interactions with reefs over 20 years', Ecology, vol. 106, no. 2.
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AbstractRecreational diving is an important activity in reef environments worldwide, providing income and employment for coastal communities and connecting visiting divers to these ecosystems promoting conservation and stewardship. However, if poorly managed, diving has the potential to cause detrimental effects on benthic communities via mechanical damage caused by physical contact of divers with the reef, often in the form of unintentional fin kicks resulting from poor buoyancy. Understanding diver–reef interaction patterns is important to elucidate the potential impacts of diving tourism on the reef biota. The DiverReef database provides the first public dataset on the underwater behavior of recreational divers in shallow reef environments (<25 m depth) globally and their interactions with the reef seascape and/or reef benthic sessile organisms. The dataset comprises 20 years of data (2004–2023) by observing the behavior of 2311 recreational divers in nine countries at 19 diving destinations and 176 diving sites; 93% of the observations were in marine protected areas. The data were collected through on‐site observations of divers' behavior during tourism activities and their physical interactions with the reef structure and/or benthic sessile reef organisms. Observers discreetly followed divers and recorded their behavior and interactions with the reef over set periods. Interactions were described as “contact” or “damage,” the latter referring to when physical damage to a benthic organism or the reef structure was observed. Besides behavior, observers also recorded data on the type of diving activity (scuba or snorkeling), profiles of the divers (gender and experience), use of cameras by the divers, visibility, type of reef formation, and marine protection status of the dive site. The authors of this research expect that the data provided will be useful in advancing knowledge of how divers interact with reefs and i...
Gilchrist, AM, McNaughton, DA, Fares, M, Wu, X, Hawkins, BA, Butler, SJ, Hibbs, DE & Gale, PA 2025, 'Tetralactam-based anion transporters', Chem, vol. 11, no. 1, pp. 102329-102329.
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Giltrap, AM, Morris, N, Dong, YY, Cochrane, SA, Krulle, T, Hoekman, S, Semmelroth, M, Wollnik, C, Palmai-Pallag, T, Carpenter, EP, Hollick, J, Parkes, A, Rudhard, Y & Davis, BG 2025, 'Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress', ACS Central Science, vol. 11, no. 1, pp. 107-115.
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Hawkins, BA, Adair, LD, Ryder, WG, Du, JJ, Najib, E, New, EJ, Gale, PA, Platts, JA, Groundwater, PW & Hibbs, DE 2025, 'Influence of Halogen Substituents on the Photophysical Properties of 7‐Hydroxycoumarin: Insights from Experimental and Theoretical Studies', ChemPhysChem, vol. 26, no. 5.
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AbstractThe benzopyrone molecule coumarin is a popular fluorescent scaffold, but how chemical modifications affect its properties is not well understood. We investigated this using halogenated 7‐hydroxycoumarin, unsubstituted 4‐methylumbiliferone, and ortho‐chloro and bromo substitutions on the phenolic ring. Charge density data from X‐Ray diffraction and computational methods revealed that halogenation at the ortho position significantly reduced quantum yield (QY). Specifically, 7‐hydroxycoumarin (1) had a QY of 70 %, while ortho‐chloro (2) and ortho‐bromo (3) had QYs of 61 % and 30 %, respectively. Experimental data showed that these molecules excited similarly, but the electrostatic potential and dipole moments indicated that 2 and 3 dissipated excitation energy more easily due to charge separation. The heavy‐atom effect of Cl and Br did not fully explain the QY reductions, suggesting other radiative decay processes were involved. By incorporating spin‐orbit coupling (SOC) effects, we estimated intersystem crossing (ISC) and phosphorescence rates, providing theoretical QYs of 78 % for 1, 59 % for 2, and 15 % for 3. The large deviation for 3 was attributed to its higher SOC potential derived in computational calculations. Our overall findings indicate that 3’s reduced QY results from a mix of SOC‐induced ISC and charge dissipation due to the electronegativity of Br atom, while 2’s reduction is primarily due to charge separation caused by Cl alone. Further studies are needed to validate this approach with other scaffolds.
Haysom‐McDowell, A, Paudel, KR, Yeung, S, Kokkinis, S, El Sherkawi, T, Chellappan, DK, Adams, J, Dua, K & De Rubis, G 2025, 'Recent trends and therapeutic potential of phytoceutical‐based nanoparticle delivery systems in mitigating non‐small cell lung cancer', Molecular Oncology, vol. 19, no. 1, pp. 15-36.
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Lung cancer is the leading cause of cancer death globally, with non‐small cell lung cancer accounting for the majority (85%) of cases. Standard treatments including chemotherapy and radiotherapy present multiple adverse effects. Medicinal plants, used for centuries, are traditionally processed by methods such as boiling and oral ingestion, However, water solubility, absorption, and hepatic metabolism reduce phytoceutical bioavailability. More recently, isolated molecular compounds from these plants can be extracted with these phytoceuticals administered either individually or as an adjunct with standard therapy. Phytoceuticals have been shown to alleviate symptoms, may reduce dosage of chemotherapy and, in some cases, enhance pharmaceutical mechanisms. Research has identified many phytoceuticals' actions on cancer‐associated pathways, such as oncogenesis, the tumour microenvironment, tumour cell proliferation, metastasis, and apoptosis. The development of novel nanoparticle delivery systems such as solid lipid nanoparticles, liquid crystalline nanoparticles, and liposomes has enhanced the bioavailability and targeted delivery of pharmaceuticals and phytoceuticals. This review explores the biological pathways associated with non‐small cell lung cancer, a diverse range of phytoceuticals, the cancer pathways they act upon, and the pros and cons of several nanoparticle delivery systems.
He, VX & Wand, MP 2025, 'The Grouped Horseshoe Distribution and Its Statistical Properties', Stat, vol. 14, no. 1.
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ABSTRACTThe Grouped Horseshoe distribution arises from hierarchical structures in the recent Bayesian methodological literature aimed at selection of groups of regression coefficients. We isolate this distribution and study its properties concerning Bayesian statistical inference. Most, but not all, of the properties of the univariate Horseshoe distribution are seen to transfer to the grouped case.
Hennessey, M, Whitefield, B, Gale, A, Kianinia, M, Scott, JA, Aharonovich, I & Toth, M 2025, 'Framework for Engineering of Spin Defects in Hexagonal Boron Nitride by Focused Ion Beams', Advanced Quantum Technologies, vol. 8, no. 2.
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AbstractHexagonal boron nitride (hBN) is gaining interest as a wide bandgap van der Waals host of optically active spin defects for quantum technologies. Most studies of the spin‐photon interface in hBN focus on the negatively charged boron vacancy (VB−) defect, which is typically fabricated by ion irradiation. However, the applicability and wide deployment of VB− defects is limited by VB− fabrication methods which lack robustness and reproducibility, particularly when applied to thin flakes (≲10 nm) of hBN. Here, two key factors are elucidated that underpin the formation and quenching of VB− centers by ion irradiation—density of defects generated in the hBN lattice and recoil‐implantation of foreign atoms into hBN. Critically, it is shown that the latter is extremely efficient at inhibiting the generation of optically‐active VB− centers. This is significant because foreign atoms such as carbon are commonplace on both the top and bottom surfaces of hBN during ion irradiation, in the form of hydrocarbon contaminants, polymer residues from hBN transfer methods, protective capping layers and substrates. Recoil implantation must be accounted for when selecting ion beam parameters such as ion mass, energy, fluence, incidence angle, and sputter/span yield, which are discussed in the context of a framework for VB− generation by high‐resolution focused ion beam (FIB) systems.
Hibberd, K & Lim, CED 2025, 'Regulation of Chinese medicine practitioners in Australia 2024: Ensuring public safety and professional standards', Journal of Traditional Chinese Medical Sciences, vol. 12, no. 1, pp. 10-12.
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Hill, M, Stapleton, S, Nguyen, PT, Sais, D, Deutsch, F, Gay, VC, Marsh, DJ & Tran, N 2025, 'The potential regulation of the miR-17–92a cluster by miR-21', The International Journal of Biochemistry & Cell Biology, vol. 178, pp. 106705-106705.
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Huang, C, Yu, J, Yue Zhang, C, Cui, Z, He, R, Yang, L, Nan, B, Li, C, Qi, X, Qi, X, Li, J, Yuan Zhou, J, Usoltsev, O, Simonelli, L, Arbiol, J, Lei, Y, Sun, Q, Wang, G & Cabot, A 2025, 'Anionic Doping in Layered Transition Metal Chalcogenides for Robust Lithium‐Sulfur Batteries', Angewandte Chemie International Edition, vol. 64, no. 8.
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AbstractLithium‐sulfur batteries (LSBs) are among the most promising next‐generation energy storage technologies. However, a slow Li−S reaction kinetics at the LSB cathode limit their energy and power densities. To address these challenges, this study introduces an anionic‐doped transition metal chalcogenide as an effective catalyst to accelerate the Li−S reaction. Specifically, a tellurium‐doped, carbon‐supported bismuth selenide with Se vacancies (Te−Bi2Se3–x@C) is prepared and tested as a sulfur host in LSB cathodes. X‐ray absorption and in situ X‐ray diffraction analyses reveal that Te doping induces lattice distortions and modulates the local coordination environment and electronic structure of Bi atoms to promote the catalytic activity toward the conversion of polysulfides. Additionally, the generated Se vacancies alter the electronic structure around atomic defect sites, increase the carrier concentration, and activate unpaired cations to effectively trap polysulfides. As a result, LSBs based on Te−Bi2Se3–x@C/S cathodes demonstrate outstanding specific capacities of 1508 mAh ⋅ g−1 at 0.1 C, excellent rate performance with 655 mAh ⋅ g−1 at 5 C, and near‐integral cycle stability over 1000 cycles. Furthermore, under high sulfur loading of 6.4 mg ⋅ cm−2, a cathode capacity exceeding 8 mAh ⋅ cm−2 is sustained at 0.1 C current rate, with 6.4 mAh ⋅ cm−2 retained after 300 cycles under lean electrolyte conditions (6.8 μL ⋅ mg−1).
Karami, H, Thurn, B, de Boer, NK, Ramos, J, Covington, JA, Lozano, J, Liu, T, Zhang, W, Su, S & Ueland, M 2025, 'Application of gas sensor technology to locate victims in mass disasters – a review', Natural Hazards, vol. 121, no. 1, pp. 31-60.
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Abstract The occurrence of mass disasters are increasing as a result of changing climates and the growing threat of terrorist activities/conflicts. When these tragedies strike, it is critical to locate victims. While search and rescue dogs are trained to locate the living, cadaver detection dogs are trained to locate the deceased. These dogs rely on the volatile organic compounds (VOCs) emitted from the victims to do so. Knowing which dog unit to deploy can be challenging, and the victims’ makeup is likely to change following disasters in densely inhabited places, where commingling is likely to occur. The use of electronic nose technologies in forensic science is a recent breakthrough. Due to their ability to detect differing VOCs, this technology can be used to assist in the recovery of victims in disaster events. The most popular types of accessible gas sensor technologies are briefly introduced and compared in this article for their potential use to locate missing persons, both living and deceased. The current and future market needs are articulated, and the lack of enrichment of these needs is examined in relation to the capabilities of existing gas sensors. This will inform further research areas of preference to increase victim detection capabilities.
Kim, J, Li, M, Lin, C, Hu, L, Wan, T, Saeed, A, Guan, P, Feng, Z, Kumeria, T, Tang, J, Su, D, Wu, T & Chu, D 2025, 'Synergetic Phase Modulation and N‐Doping of MoS2 for Highly Sensitive Flexible NO2 Sensors', Advanced Science, vol. 12, no. 4.
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AbstractMolybdenum disulfide (MoS2) is a promising electronic material owing to its excellent electrochemical features, high carrier mobility at room temperature, and widely tunable electronic properties. Here, through precursor engineering and post‐treatments to tailor their phase and doping, electronic characteristics of MoS2 are significantly modified. It is found that 2H semiconductor phase with nitrogen doping (N‐doping) in flexible gas sensors constructed with Ag electrodes exhibits the highest sensitivity of ≈2500% toward 10 ppm of NO2. This sensitivity is ≈17‐ and 417‐folds higher than that of 2H MoS2 without N‐doping, and mixed phases with metallic 1T and semiconductor 2H phase, respectively. Comprehensive experimental investigations reveal mechanisms underlying this record sensitivity, that is, the use of N‐doped 2H MoS2 sensors not only significantly suppresses dark current but also effectively enhances electron transfer to NO2 molecules. Moreover, density function theory calculations underpin the experimental results, confirming that N2H4 molecules from the precursor solution not only promote phase transition but also enable N‐doping during post‐treatments, thus boosting sensing capability. This work, for the first time, reveals the synergistic effect of phase modulation and N‐doping of MoS2, which can be readily used in other flexible electronic applications, advancing MoS2‐based electronics to a new stage.
Krosch, MN, Johnston, NP, Law, K, Wallman, JF & Archer, MS 2025, 'Retrospective review of forensic entomology casework in eastern Australia from 1994 to 2022', Forensic Science International, vol. 367, pp. 112355-112355.
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Kusrini, E, Nuzula, K, Usman, A, Wilson, LD, Gunawan, C & Prasetyo, AB 2025, 'Enhanced Cytotoxicity and Antifungal Effects of Iron-Oxide Chitosan/Samarium/Ranitidine Microparticles', Sains Malaysiana, vol. 54, no. 1, pp. 3673-3686.
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This study aimed to investigate the cytotoxicity and antifungal properties of Sm(NO3)3.6H2O salt, chitosan/Sm complex, iron oxide (Fe3O4 NPs), and iron-oxide modified chitosan/Sm/ranitidine microparticles. The microparticles of iron-oxide modified chitosan/Sm/ranitidine composites were synthesized from various masses of Sm(NO3)3.6H2O (250-350 mg), chitosan (2,000-2,500 mg), and (5-25 mg) through the microwave-assisted evaporation method. The Fe3O4 NPs and ranitidine/Sm were mixed with chitosan through a dispersion method by microwave. The toxicity studies of iron-oxide modified chitosan/Sm/ranitidine composites showed 50% lethal concentration in the range from 3,600 to 3,900 µg/mL on the aquatic crustacean Artemia salina, suggesting their slight toxicity. Antifungal activities for all samples were determined using the agar diffusion and serial dilution methods. The iron-oxide modified chitosan/Sm/ranitidine composites showed inhibition zone diameter of Aspergillus niger from 18.33 to 14.67 mm at 1,000 µg/mL. All composites and chitosan/Sm complex showed bioactivity properties with minimum inhibitory concentration values of 2.5 µg/mL against A. niger. These composites and chitosan/Sm complex have the same minimum fungicidal concentration, showing the potential to inhibit fungi. Overall results suggested that modifying the structure of chitosan using Sm3+, Fe3O4 NPs, and ranitidine enhanced its physical, chemical, and biological properties as an antifungal agent.
Labara Tirado, J, Herdean, A & Ralph, PJ 2025, 'The need for smart microalgal bioprospecting', Natural Products and Bioprospecting, vol. 15, no. 1.
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Abstract Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic microorganisms into a biotechnological source of industrially relevant physiological functions and biometabolites. Despite this, microalgae-based industries only exploit a handful of species. This lack of biodiversity hinders the expansion of the microalgal industry. Microalgal bioprospecting, searching for novel biological algal resources with new properties, remains a low throughput and time-consuming endeavour due to inefficient workflows that rely on non-selective sampling, monoalgal culture status and outdated, non-standardized characterization techniques. This review will highlight the importance of microalgal bioprospecting and critically explore commonly employed methodologies. We will also explore current advances driving the next generation of smart algal bioprospecting focusing on novel workflows and transdisciplinary methodologies with the potential to enable high-throughput microalgal biodiscoveries. Images adapted from (Addicted04 in Wikipedia File: Australia on the globe (Australia centered).svg. 2014.; Jin et al. in ACS Appl Bio Mater 4:5080–5089, 2021; Kim et al. in Microchim Acta 189:88, 2022; Tony et al. in Lab on a Chip 15, 19:3810–3810; Thermo Fisher Scientific INC. in CTS Rotea Brochure). Graphical abstract
Lalor, R, Tanaka, A, Shiels, J, Dixit, A, Hoadley, S, Dufourd, E, Hamon, S, To, J, Taggart, CC, Weldon, S, O'Brien, B, Greer, J, Dalton, JP & Donnelly, S 2025, 'An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis', The FASEB Journal, vol. 39, no. 4.
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AbstractThe helminth defense molecules (HDM) are a family of immune regulatory peptides exclusively expressed by trematode worms. We have previously demonstrated that in vivo FhHDM‐1, the archetypal member of the HDMs, regulated macrophage responses to inflammatory ligands, thereby ameliorating the progression of immune‐mediated tissue damage in several murine models of inflammatory disease. Accordingly, we postulated that an understanding of the structure–function relationship of the HDMs would facilitate the identification of the minimal bioactive peptide, which would represent a more synthesizable, cost‐effective, potent biotherapeutic. Thus, using a combination of bioinformatics, structural analyses, and cellular assays we discovered a 40 amino acid peptide derivative termed FhHDM‐1.C2. This peptide contains a 12 amino acid motif at its N‐terminus, which facilitates cellular interaction and uptake, and an amphipathic α‐helix within the C‐terminus, which is necessary for lysosomal vATPase inhibitory activity, with both regions linked by a short unstructured segment. The FhHDM‐1.C2 peptide exhibits enhanced regulation of macrophage function, compared with the full‐length FhHDM‐1, and potent prevention of the progression of relapsing–remitting‐experimental autoimmune encephalomyelitis (EAE) when administered prophylactically or therapeutically. The protective effect of FhHDM‐1.C2 is not associated with global immune suppression, which places the HDMs peptides as an improved class of biotherapeutics for the treatment of inflammatory diseases. Comparing the HDMs from several zoonotic trematodes revealed a similar capacity for immune regulation. These important new advances into the structure–function relationship of the lead HDM peptide, FhHDM‐1, encourage further prospecting and screening of the broader trematode family of peptides for the discovery of novel and potent immune‐biotherapeutics.
Lau, V, Roux, C & Spindler, X 2025, 'The persistence of fibres following a choreographed assault: A quantitative assessment of the influence of physical activity', Science & Justice, vol. 65, no. 2, pp. 103-118.
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Le Bas, A, Clarke, BR, Teelucksingh, T, Lee, M, El Omari, K, Giltrap, AM, McMahon, SA, Liu, H, Beale, JH, Mykhaylyk, V, Duman, R, Paterson, NG, Ward, PN, Harrison, PJ, Weckener, M, Pardon, E, Steyaert, J, Liu, H, Quigley, A, Davis, BG, Wagner, A, Whitfield, C & Naismith, JH 2025, 'Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide', Open Biology, vol. 15, no. 1.
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The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy whereby the newly synthesized lipid-linked repeat units, lipid III, are transferred across the inner membrane by the lipid III flippase WzxE. WzxE is part of the Wzx family and required in many glycan assembly systems, but an understanding of its molecular mechanism is hindered due to a lack of structural evidence. Here, we present the first X-ray structures of WzxE from Escherichia coli in complex with nanobodies. Both inward- and outward-facing conformations highlight two pairs of arginine residues that move in a reciprocal fashion, enabling flipping. One of the arginine pairs coordinated to a glutamate residue is essential for activity along with the C-terminal arginine rich tail located close to the entrance of the lumen. This work helps understand the translocation mechanism of the Wzx flippase family.
Li, J, Catal, O, Marques, I, McNaughton, DA, Maklad, RM, Ryder, WG, Hill, MJS, Seddon, A, Lewis, W, Adams, DJ, Félix, V, Wu, X & Gale, PA 2025, 'Trapping Anions within Stacks of Tetra-Urea Macrocycles', Journal of the American Chemical Society, vol. 147, no. 4, pp. 3392-3401.
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Li, R, Wang, J, Zhao, X, Liu, Z, Jia, P, Liu, Y, Lin, G, Xu, H & Xiong, J 2025, 'Small-scale magnetic soft robotic catheter for in-situ biomechanical force sensing', Biosensors and Bioelectronics, vol. 270, pp. 116977-116977.
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Li, T, Datson, Z, Birvé, AP, Ciampi, S, Fallon, T, Kosov, DS, Reimers, JR & Darwish, N 2025, 'Toward Piezoresistive Devices That Exploit Bullvalene’s Structural Versatility', Langmuir, vol. 41, no. 8, pp. 5410-5418.
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Li, Y, Cherepanoff, S, Conway, RM, Hesson, LB, Long, G, Garg, N & Fung, AT 2025, 'Choroidal melanoma in a patient with multiple endocrine neoplasia type 1', Canadian Journal of Ophthalmology, vol. 60, no. 1, pp. e173-e176.
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Lim, ECN, Cheng, NCL & Lim, CED 2025, 'Beyond Infection: A Case of Doxycycline-Induced Mania and Prolonged Neuropsychiatric Disturbance', Cureus.
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Lim, Y, Kim, RM, Han, JH, Aharonovich, I, Nam, KT & Kim, S 2025, 'Strong Chiral Response of Chiral Plasmonic Nanoparticles to Photonic Orbital Angular Momentum', Advanced Optical Materials, vol. 13, no. 5.
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AbstractChiral plasmonic nanomaterials have been widely utilized to study light‐matter interactions due to its capability to amplify chiroptic signals. Conventionally, chiro‐optic experiments have demonstrated interactions between circularly polarized light and materials. However, employing light with chiral phase, i.e., optical vortex, can generate a strong chiral response and holds the potential to unveil extensive material information owing to the infinite topological numbers. In this work, an array of 3D chiral nanoparticles is employed to demonstrate large helical dichroism (HD). Chiral gold nanoparticle arrays are illuminated by vortex beams of opposite helicity, which revealed the high HD value of 0.93. The chiral interaction is theoretically investigated, and enantioselective interaction can be explained by multipole analysis. It is determined that the strong HD is attributed to the interaction of higher‐order multipole moments such as electric quadrupole and magnetic quadrupole moments. This study provides deeper insight into understanding of the interaction between optical vortex and chiral plasmonic nanostructures and paves the way for next‐generation chiroptical applications ranging from ultrasensitive chiral spectroscopy to chiral quantum optics.
Lin, C-H, Tang, P-W & Huete, AR 2025, 'Quantum Feature-Empowered Deep Classification for Fast Mangrove Mapping', IEEE Transactions on Geoscience and Remote Sensing, vol. 63, pp. 1-13.
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Lin, X, Zhang, Y, Li, J, Oliver, BG, Wang, B, Li, H, Yong, K-T & Li, JJ 2025, 'Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects', Bioactive Materials, vol. 43, pp. 510-549.
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Lin, X, Zhao, H, Zhang, S, He, Q, Huete, A, Yang, L, Zhang, X, Zhang, X, Zhang, Q & Cai, S 2025, 'Grassland irrigation and grazing prohibition have significantly affected vegetation and microbial diversity by changing soil temperature and moisture, evidences from a 6 years experiment of typical temperate grassland', Agriculture, Ecosystems & Environment, vol. 380, pp. 109414-109414.
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Liu, G, Hsu, AC, Geirnaert, S, Cong, C, Nair, PM, Shen, S, Marshall, JE, Haw, TJ, Fricker, M, Philp, AM, Hansbro, NG, Pavlidis, S, Guo, Y, Burgess, JK, Castellano, L, Ieni, A, Caramori, G, Oliver, BGG, Chung, KF, Adcock, IM, Knight, DA, Polverino, F, Bracke, K, Wark, PA & Hansbro, PM 2025, 'Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease', Molecular Therapy, vol. 33, no. 3, pp. 917-932.
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Liu, M, Song, A, Zhang, X, Wang, J, Fan, Y, Wang, G, Tian, H, Ma, Z & Shao, G 2025, 'Interfacial lithium-ion transportation in solid-state batteries: Challenges and prospects', Nano Energy, vol. 136, pp. 110749-110749.
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Liu, X, Shu, Y, Zhu, J, Fang, H, Su, Y, Ma, H, Li, B, Xu, J, Cheng, YY, Pan, B & Song, K 2025, 'A 3D bioprinted potential colorectal tumor model based on decellularized matrix/gelatin methacryloyl/nanoclay/sodium alginate hydrogel', International Journal of Biological Macromolecules, vol. 293, pp. 139346-139346.
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Lockwood, TE, Bordin, DCM, Westerhausen, MT & Bishop, DP 2025, 'Preparation of gelatine calibration standards for LA-ICP-MS bioimaging with 266 nm laser ablation systems', Talanta, vol. 283, pp. 127150-127150.
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Luo, Y, Luo, Y, Liu, Y, Huang, Y, Yu, P, Ma, H, Li, X, Zhang, Z, Zhang, C, Chen, C, Gale, PA & Bao, G 2025, 'A hybrid strategy to enhance small-sized upconversion nanocrystals', Biosensors and Bioelectronics, vol. 271, pp. 117003-117003.
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Lust, B, Matthews, JL, Oakley, CA, Lewis, RE, Mendis, H, Peng, L, Grossman, AR, Weis, VM & Davy, SK 2025, 'The Influence of Symbiont Identity on the Proteomic and Metabolomic Responses of the Model Cnidarian Aiptasia to Thermal Stress', Environmental Microbiology, vol. 27, no. 3.
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ABSTRACTWe examined the effects of symbiont identity and heat stress on the host metabolome and proteome in the cnidarian–dinoflagellate symbiosis. Exaiptasia diaphana (‘Aiptasia’) was inoculated with its homologous (i.e., native) symbiont Breviolum minutum or a heterologous (i.e., non‐native) symbiont (Symbiodinium microadriaticum; Durusdinium trenchii) and thermally stressed. Integrated metabolome and proteome analyses characterised host thermal responses between symbioses, with clear evidence of enhanced nutritional deprivation and cellular stress in hosts harbouring heterologous symbionts following temperature stress. Host metabolomes were partially distinct at the control temperature; however, thermal stress caused metabolomes of anemones containing the two heterologous symbionts to become more alike and more distinct from those containing B. minutum. While these patterns could be partly explained by innate symbiont‐specific differences, they may also reflect differences in symbiont density, as under control conditions D. trenchii attained 60% and S. microadriaticum 15% of the density attained by B. minutum, and at elevated temperature only D. trenchii–colonised anemones bleached (60% loss). Our findings add to a growing literature that highlights the physiological limits of partner switching as a means of adaptation to global warming. However, we also provide tentative evidence for improved metabolic functioning with a heterologous s...
Ma, C, Tang, X, Ben, H, Jiang, W, Shao, X, Wang, G & Sun, B 2025, 'Promoting Reaction Kinetics and Boosting Sodium Storage Capability via Constructing Stable Heterostructures for Sodium‐Ion Batteries', Advanced Functional Materials, vol. 35, no. 2.
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AbstractConstructing heterostructures containing multiple active components is proven to be an efficient strategy for enhancing the sodium storage capability of anode materials in sodium‐ion batteries (SIBs). However, performance enhancement is often attributed to the unclear synergistic effects among the active components. A comprehensive understanding of the reaction mechanisms on the interfaces at the atomic level remains elusive. Herein, the carbon‐coated Fe3Se4/CoSe (Fe3Se4/CoSe‐C) anode material as a model featuring atomic‐scale contact interfaces is synthesized. This unique heterogeneous architecture offers an adjustable electronic structure, which facilitates rapid reaction kinetics and enhances structural integrity. In situ microscopic and ex situ spectral characterization techniques, along with theoretical simulations, confirm that the heterointerface with strong electric fields promotes Na+ ion migration. Based on solid‐state nuclear magnetic resonance (NMR) analysis, an interface charge storage mechanism is revealed, resulting in the enhanced specific capacity of the anode materials. When employed as an anode in SIBs, the Fe3Se4/CoSe‐C electrode demonstrates excellent rate capabilities (218 mAh g−1 at 7 A g−1) and prolonged cycling stability (258 mAh g−1 at 5 A g−1 after 1000 cycles). This work highlights the significance of heterointerface engineering in electrode material design for rechargeable batteries.
Ma, W, Cui, X, Chen, Y, Wan, S, Zhao, S, Gong, J, Wang, G & Chen, S 2025, 'Designing a Refined Multi‐Structural Polymer Electrolyte Framework for Highly Stable Lithium‐Metal Batteries', Angewandte Chemie International Edition, vol. 64, no. 3.
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AbstractRational structural designs of solid polymer electrolytes featuring rich interface‐phase morphologies can improve electrolyte connection and rapid ion transport. However, these rigid interfacial structures commonly result in diminished or entirely inert ionic conductivity within their bulk phase, compromising overall electrolyte performance. Herein, a multi‐component ion‐conductive electrolyte was successfully designed based on a refined multi‐structural polymer electrolyte (RMSPE) framework with uniform Li+ solvation chemistry and rapid Li+ transporting kinetics. The RMSPE framework is constructed via polymerization‐induced phase separation based on a rational combination of lithiophilic components and rigid/flexible chain units with significant hydrophobic/hydrophilic contrasts. Further refined by coating a robust polymer network, this all‐organic design endows a homogeneous micro‐nano porous structure, providing a novel framework favorable for rapid ion transport in both its soft interfacial and bulk phases. The RMSPE exhibited excellent ion conductivity of 1.91 mS cm−1 at room temperature and a high Li+ transference number of 0.7. Assembled symmetrical Li cells realized stable cycling for over 2400 h at 3.0 mA cm−2. LiFePO4 full batteries demonstrated a long lifespan of 3300 cycles with a capacity retention of 93.5 % and stable cycling performance at −35 °C. This innovative design concept offers a promising perspective for achieving high‐performance polymer‐based Li metal batteries.
Maestrini, L, Aykroyd, RG & Wand, MP 2025, 'A variational inference framework for inverse problems', Computational Statistics & Data Analysis, vol. 202, pp. 108055-108055.
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Mao, K, Liu, C, Ni, A, Wang, J, Sun, J, Wang, G, Xiong, P & Zhu, J 2025, 'Optimization of ion transport in two-dimensional nanofluidic membranes for osmotic energy conversion', Materials Today, vol. 82, pp. 274-288.
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Marsh, DJ, Mulligan, LM, Ngeow, J, Ringel, MD & Stratakis, CA 2025, 'In memoriam: Charis Eng MD PhD (1962–2024)', Endocrine-Related Cancer, vol. 32, no. 1.
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Matthew Ringel On behalf of the entire editorial team of Endocrine-Related Cancer, and personally as trainees and collaborators who at present serve as associate or senior editors of the Journal, it is with profound sadness that we write this memorial to Prof. Charis Eng, M.D., Ph.D who passed away on August 13, 2024. Prof. Eng served as Editor-in-Chief of Endocrine-Related Cancer from 2011-2021 and was dedicated to the Journal before, during, and after she served in that role. She had remarkable impact on Endocrine-Related Cancer moving the journal forward with great vision and energy while maintaining the strongest commitments to publishing the highest quality original research and reviews applying fair, ethical, and rigorous peer-review processes. Charis was a world-recognized leader in cancer genomics and clinical genetics medicine who enabled growth in Endocrine-Related Cancer in these and other areas critical for advancement of research and clinical care of endocrine cancers. She will be remembered by all of us as a superb and consequential researcher, editor, physician, leader, teacher, mentor, colleague, and friend.
McNevin, D, Watson, J, Grisedale, K, Dahal, A, Goodwin, C & Ward, J 2025, 'Comparison of commercial targeted amplicon sequencing assays for human remains identification casework', International Journal of Legal Medicine, vol. 139, no. 1, pp. 49-60.
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Abstract Targeted amplicon sequencing (TAS) facilitates the genotyping of forensically informative single nucleotide polymorphisms (SNPs) using massively parallel sequencing (MPS). For human remains identification, where any extracted DNA is likely to be degraded, TAS may succeed when short tandem repeat (STR) profiling using capillary electrophoresis fails. Further, as well as yielding identity information, SNPs can provide information about ancestry, phenotype, kinship and paternal lineage (Y chromosome haplotypes). Two TAS platforms were compared in this study: Ion AmpliSeq™ panels coupled with Ion Torrent sequencing on an Ion GeneStudio™ S5 Plus System, manufactured by Thermo Fisher Scientific, and the ForenSeq® Kintelligence Kit coupled with Illumina sequencing on the MiSeq FGx® Sequencing System, manufactured by QIAGEN. Four Ion AmpliSeq™ panels (Precision ID Identity, Precision ID Ancestry, DNA Phenotyping and HID Y-SNP) share 177 SNPs with the ForenSeq® Kintelligence Kit and all five were used to profile the DNA extracted from the petrous part of the temporal bone from six skeletonised cadavers. Of the 6 × 177 = 1,062 SNP genotype comparisons, 1,055 (99%) were concordant between the Ion AmpliSeq™ panels and Kintelligence Kit. Of the seven (< 1%) non-concordant SNPs, only three of them (0.3%) would have resulted in erroneous genotypes being reported as a result of allele dropout by either assay, using our optimised relative variant frequency windows for allele calling. We conclude that both the Ion AmpliSeq™ panels and the ForenSeq® Kintelligence Kit were suitable for TAS applied to the human remains in this study.
Moneer, EA, Akl, SH, Shahin, YH, Shahin, SH, Elwakil, BH, Eskandrani, A, Paudel, KR & Bakr, BA 2025, 'The antiparasitic effect of C-Phycocyanin nanoparticles on cryptosporidiosis in immunosuppressed mice', Journal of Parasitic Diseases, vol. 49, no. 1, pp. 173-185.
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Moodley, C, Mallick, K, Muller, A & Williams, DBG 2025, 'Transition‐ and Lanthanide‐Metal‐Based Coordination Polymers Offer Efficient Methylene Blue Adsorption', ChemistrySelect, vol. 10, no. 4.
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AbstractThis study presents a novel approach toward wastewater remediation via the synthesis of a series of coordination polymers that combine benzene‐1,4‐dicarboxylic acid, benzene‐1,4‐dihydroxamic acid, and 5‐nitroisophthalic acid linkers with Cu, Cr, Ce, and La metal salts to target efficient methylene blue removal. Through a detailed characterization process using techniques like ¹H NMR, PXRD, FTIR, TGA, SEM‐EDX, ICP‐OES, and BET, the structural and surface properties of these CPs were optimized for stability and enhanced adsorption performance. Notably, the CPs exhibited rapid MB adsorption within 10 min and followed pseudo‐second‐order kinetics, indicating a chemisorption‐driven process. This work advances the field by demonstrating that increased pH significantly improves adsorption capacity and that the Sips model best describes the heterogeneous adsorptive behavior, highlighting a mixed Langmuir–Freundlich mechanism. Furthermore, stability and reusability studies revealed minimal metal leaching in the best‐performing CPs, addressing critical environmental concerns around long‐term CP use. This integrated approach not only fills vital knowledge gaps in CP‐based dye adsorption kinetics but also underscores the potential of these materials as sustainable, scalable, and effective solutions for real‐world water treatment applications.
Nair, SG, Nguyen, QD, Zhu, Q, Karimi, M, Gan, Y, Wang, X, Castel, A, Irga, P, Rocha, CGD, Torpy, F, Wilkinson, S, Moreau, D & Delhomme, F 2025, 'Suitability of calcined clay and ground granulated blast furnace slag geopolymer binder for hempcrete applications', Built Environment Project and Asset Management.
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PurposeHempcrete has the potential to reduce both CO2 emissions and energy usage in buildings. Hempcrete has a high sound absorption capacity, excellent moisture regulator and outstanding thermal insulation properties. However, hempcrete traditionally uses lime-based binders, which are carbon-intensive materials. The low-carbon binders to increase the sustainability of hempcrete are the current research gap. Geopolymer binders are low-carbon binders composed of aluminosilicate precursors dissolved in a high alkalinity solution. This study investigated the suitability of calcined clay and ground granulated blast furnace slag geopolymer binder as a low-carbon binder for hempcrete applications.Design/methodology/approachTwo types of hemp hurds with different water absorption capacity and particle size distributions were used. Hempcrete properties tested were compressive strength, bulk density, sound absorption coefficient by a two-microphone impedance tube and thermal conductivity by a Hot Disk system.FindingsThe particle size distribution and water absorption capacity of hemp hurds did not affect the compressive strength of hempcrete when following a mixing procedure, ensuring the hurds in a saturated surface dry condition. The geopolymer hempcrete achieved a compressive strength about four times higher than the reference hydrated lime hempcrete. All hempcrete specimens achieved outstanding acoustic performance. The increase in bulk density led to the decrease in the maximum sound absorption coefficient. The geopolymer hempcrete achieved the lowest thermal conductivity.Originality/value
Neale, DA, Morris, JC, Verrills, NM & Ammit, AJ 2025, 'Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics', Pharmacology & Therapeutics, pp. 108834-108834.
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Nguyen, HAD, Le, HT, Barthelemy, X, Azzi, M, Duc, H, Jiang, N, Riley, M & Ha, QP 2025, 'A Deep-Learning-Based Visualization Tool for Air Pollution Forecasting', IEEE Software, vol. 42, no. 2, pp. 47-56.
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Noble, DWA, Xirocostas, ZA, Wu, NC, Martinig, AR, Almeida, RA, Bairos-Novak, KR, Balti, H, Bertram, MG, Bliard, L, Brand, JA, Byrne, I, Chan, Y-C, Clink, DJ, Corbel, Q, Correia, RA, Crawford-Ash, J, Culina, A, D'Bastiani, E, Deme, GG, de Souza Leite, M, Dhellemmes, F, Dimri, S, Drobniak, SM, Elsy, AD, Everingham, SE, Gascoigne, SJL, Grainger, MJ, Hossack, GC, Hovstad, KA, Ivimey-Cook, ER, Jones, ML, Kačergytė, I, Küstner, G, Leibold, DC, Mair, MM, Martin, J, Mizuno, A, Moodie, IR, Moreau, D, O'Dea, RE, Orr, JA, Paquet, M, Parajuli, R, Pick, JL, Pottier, P, Purgar, M, Recio, P, Roche, DG, Royauté, R, Shafiei Sabet, S, Segovia, JMG, Silva, I, Sánchez-Tójar, A, Soares, BE, Szabo, B, Takola, E, Thoré, ESJ, Timilsina, B, van Dis, NE, Verberk, WCEP, Vriend, SJG, Wild, KH, Williams, C, Yang, Y, Nakagawa, S & Lagisz, M 2025, 'The promise of community-driven preprints in ecology and evolution', Proceedings of the Royal Society B: Biological Sciences, vol. 292, no. 2039.
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Publishing preprints is quickly becoming commonplace in ecology and evolutionary biology. Preprints can facilitate the rapid sharing of scientific knowledge establishing precedence and enabling feedback from the research community before peer review. Yet, significant barriers to preprint use exist, including language barriers, a lack of understanding about the benefits of preprints and a lack of diversity in the types of research outputs accepted (e.g. reports). Community-driven preprint initiatives can allow a research community to come together to break down these barriers to improve equity and coverage of global knowledge. Here, we explore the first preprints uploaded to EcoEvoRxiv ( n = 1216), a community-driven preprint server for ecologists and evolutionary biologists, to characterize preprint use in ecology, evolution and conservation. Our perspective piece highlights some of the unique initiatives that EcoEvoRxiv has taken to break down barriers to scientific publishing by exploring the composition of articles, how gender and career stage influence preprint use, whether preprints are associated with greater open science practices (e.g. code and data sharing) and tracking preprint publication outcomes. Our analysis identifies areas that we still need to improve upon but highlights how community-driven initiatives, such as EcoEvoRxiv , can play a crucial role in shaping publishing practices in biology.
Novikov, AA, Shiryaev, AN & Kordzakhia, NE 2025, 'On Parameter Estimation of Diffusion-Type Processes: Sequential Estimation Revisited', Theory of Probability & Its Applications, vol. 69, no. 4, pp. 531-552.
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Ohiagu, FO, Chikezie, PC, Maduka, TO, Chikezie, CM, Nwaiwu, O & Paudel, KR 2025, 'Antioxidants, Radical Scavengers, and Their Impact on Oxidative Stress', Free Radicals and Antioxidants, vol. 14, no. 2, pp. 62-85.
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Oliver, BG, Wang, J, Yarak, RA, Hikasem, T, Wang, B, Feng, M, Wang, X, Gorrie, CA, Yi, C & Chen, H 2025, 'Exposure to third hand e-cigarette vapour impairs cognitive function in young mice', Ecotoxicology and Environmental Safety, vol. 291, pp. 117885-117885.
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Pan, X, Jian, Y, An, N, Xie, R-J, Ke, S, Li, Z, Wang, H, Lin, C, Zhuang, Y, Zhou, J, Mei, L & Liao, L 2025, 'Innovations in phosphate phosphors: Bridging structure-property gaps for enhanced luminescence', Coordination Chemistry Reviews, vol. 528, pp. 216407-216407.
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Park, J, Cho, J, Lee, NJ, Lee, H, Lee, J, Lee, G, Marlton, FP, Suzuki, M, Hinterstein, M, Oh, YS, Choi, J, Hwang, G, Lee, JH, Kim, S, Kim, KH & Jo, W 2025, 'Enhanced Coupling Between Soft Ferromagnetism and Displacive Ferroelectricity in the Pb‐Site Modified PbFe1/2Nb1/2O3', Advanced Electronic Materials, vol. 11, no. 2.
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AbstractAlbeit having great potential toward unprecedented type of applications such as magnetoelectric (ME) sensors and memories, practically useful single‐phase multiferroics that show large coupling between ferromagnetism and ferroelectricity at ambient temperatures are still lacking. Here, the discovery of a new type of perovskite ferroelectrics (Pb,M)(Fe1/2Nb1/2)O3 (M = Fe, Co, Ni) is reported with a magnetically‐active metal ion introduced into a cuboctahedrally‐coordinated Pb position, which exhibits enhanced ME coupling owing to the development of simultaneous soft‐ferromagnetism and lone‐pair ferroelectricity persistent above room temperature. These Pb‐site engineered (Pb,M)(Fe1/2Nb1/2)O3 perovskites exhibit a ME coupling coefficient of ≈40–60 ps m−1, a saturated electric polarization of 14–17 µC cm−2 and a saturation magnetization of 0.15–0.3 µB f.u−1. X‐ray absorption spectroscopy combined with first‐principles calculations demonstrates that the induced ferromagnetism originates from the ferromagnetic superexchange interaction coming from ≈90° bonding between the magnetic ions at the Pb site. The present discovery of the enhanced ME coupling in the Pb‐site engineered perovskite ferroelectrics may provide unforeseen opportunities for applying conventional displacive ferroelectricity in the field of spintronics where ferromagnetism is essentially required.
Parmar, DR, Johnston, NP, Wallman, JF & Szpila, K 2025, 'Blowfly genomics: current insights, knowledge gaps, and future perspectives', Current Opinion in Insect Science, vol. 68, pp. 101305-101305.
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Patel, MN, Patel, AJ, Nandpal, MN, Raval, MA, Patel, RJ, Patel, AA, Paudel, KR, Hansbro, PM, Singh, SK, Gupta, G, Dua, K & Patel, SG 2025, 'Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 398, no. 3, pp. 2127-2150.
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Drug-resistant tuberculosis (DR-TB) represents a pressing global health issue, leading to heightened morbidity and mortality. Despite extensive research efforts, the escalation of DR-TB cases underscores the urgent need for enhanced prevention, diagnosis, and treatment strategies. This review delves deep into the molecular and genetic origins of different types of DR-TB, highlighting recent breakthroughs in detection and diagnosis, including Rapid Diagnostic Tests like Xpert Ultra, Whole Genome Sequencing, and AI-based tools along with latest viewpoints on diagnosis and treatment of DR-TB utilizing newer and repurposed drug molecules. Special emphasis is given to the pivotal role of novel drugs and discusses updated treatment regimens endorsed by governing bodies, alongside innovative personalized drug-delivery systems such as nano-carriers, along with an analysis of relevant patents in this area. All the compiled information highlights the inherent challenges of current DR-TB treatments, discussing their complexity, potential side effects, and the socioeconomic strain they impose, particularly in under-resourced regions, emphasizing the cost-effective and accessible solutions. By offering insights, this review aims to serve as a compass for researchers, healthcare practitioners, and policymakers, emphasizing the critical need for ongoing R&D to improve treatments and broaden access to crucial TB interventions.
Rafiezadeh, S, Irvine, C, Salih, AK, Mousavi, M, Phillips, MR, Ghasemian, MB & Ton-That, C 2025, 'Enhanced Luminescence and Photocatalytic Activity in Highly Inverted Spinel ZnGa2O4 Nanoplates', ACS Applied Nano Materials, vol. 8, no. 2, pp. 1033-1041.
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Rennie, C, Morshed, N, Faria, M, Collins-Praino, L & Care, A 2025, 'Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid', Molecular Pharmaceutics, vol. 22, no. 2, pp. 940-957.
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Ross, A, Lennard, C & Roux, C 2025, 'Forensic science: Where to from Here?', Forensic Science International, vol. 366, pp. 112285-112285.
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Ross, PM & Scanes, E 2025, 'Using self-determination theory as a lens to create sustainable futures for teaching and education focused academics in higher education in Australia', Journal of Higher Education Policy and Management, vol. 47, no. 1, pp. 90-107.
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Runge, AFJ, Schmidt, MK, Solntsev, AS, Steel, MJ & Poulton, CG 2025, 'Quasi-solitons and stable superluminal opto-acoustic pulses in Brillouin scattering', APL Photonics, vol. 10, no. 3.
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We theoretically and numerically study the evolution of soliton-like waves supported by stimulated Brillouin scattering. First, the emergence and unusual behavior of resonant solitary waves are investigated for both backward and forward three wave interactions. We find that these waves can be characterized by the ratio between the optical and acoustic damping coefficients. We also examine a second class of non-resonant anti-symmetric soliton-like waves, which have a more complicated pulse shape than traditional solitons. These waves are superluminal, with pulse velocities that can be tuned by the input Stokes and pump fields. We discuss the excitation of these types of waves and the physical conditions required for their observation.
Ryder, WG, Levina, A, Graziotto, ME, Hawkins, BA, Hibbs, DE, New, EJ & Gale, PA 2025, 'Subcellular targeted anion transporters', Chem, vol. 11, no. 1, pp. 102247-102247.
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Salih, AK, Fiedler, S, Irvine, CP, Matar, F, Phillips, MR & Ton-That, C 2025, 'Defect passivation and enhanced UV emission in β-Ga2O3 via remote fluorine plasma treatment', Applied Surface Science, vol. 687, pp. 162250-162250.
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Salih, AK, Irvine, CP, Matar, F, Aditya, L, Nghiem, LD & Ton-That, C 2025, 'Photocatalytic self-cleansing ZnO-coated ceramic membranes for preconcentrating microalgae', Journal of Membrane Science, vol. 718, pp. 123700-123700.
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Salloum, PM, Guo, J & Scanes, E 2025, 'Molluscan microbiomes: current research focus, knowledge gaps, and future directions', Molluscan Research, vol. 45, no. 2, pp. 125-136.
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Salomon, R, Razavi Bazaz, S, Mutafopulos, K, Gallego-Ortega, D, Warkiani, M, Weitz, D & Jin, D 2025, 'Challenges in blood fractionation for cancer liquid biopsy: how can microfluidics assist?', Lab on a Chip, vol. 25, no. 5, pp. 1097-1127.
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Microfluidic blood fractionation has a critical role in enhancing liquid biopsy. Liquid biopsy allows molecular and phenotypic characteristics of a patient's tumor by detecting evidence of cancerous changes in readily accessible samples like blood.
Sarretto, T, Westerhausen, MT, Mckinnon, JC, Bishop, DP & Ellis, SR 2025, 'Evaluation of combined workflows for multimodal mass spectrometry imaging of elements and lipids from the same tissue section', Analytical and Bioanalytical Chemistry, vol. 417, no. 4, pp. 705-719.
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Abstract The wide range of mass spectrometry imaging (MSI) technologies enables the spatial distributions of many analyte classes to be investigated. However, as each approach is best suited to certain analytes, combinations of different MSI techniques are increasingly being explored to obtain more chemical information from a sample. In many cases, performing a sequential analysis of the same tissue section is ideal to enable a direct correlation of multimodal data. In this work, we explored different workflows that allow sequential lipid and elemental imaging on the same tissue section using atmospheric pressure laser desorption/ionisation-plasma post-ionisation-MSI (AP-MALDI-PPI-MSI) and laser ablation-inductively coupled plasma-MSI (LA-ICP-MSI), respectively. It is found that performing lipid imaging first using matrix-coated samples, followed by elemental imaging on matrix-coated samples, provides high-quality MSI datasets for both lipids and elements, with the resulting distributions being similar to those obtained when each is performed in isolation. The effect of matrix removal prior to elemental imaging, and of performing elemental imaging first were also investigated but found to generally yield lower quality elemental imaging data but comparable lipid imaging data. Finally, we used the ability to acquire both elemental and lipid imaging data from the same section to investigate the spatial correlations between different lipids (including ceramides, phosphatidylethanolamine, and hexosylceramides) and elements within mouse brain tissue. Graphical Abstract
Satija, S, Vyas, M, Pandey, P & Garg, M 2025, 'Taguchi L9 Optimization of Microwave‐Assisted Solid–Liquid Duo Heating for Berberine Extraction With HPTLC Analysis', Biomedical Chromatography, vol. 39, no. 3.
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ABSTRACTWe present an optimized approach for the extraction of berberine using microwave‐assisted solid–liquid duo heating. The conventional procedure relies on the simultaneous heating of the sample matrix and the dissolving solvent under microwave energy. To improve the efficiency of this process, we employed the Taguchi L9 orthogonal design methodology, focusing on key extraction parameters, including microwave power, irradiation time, solute‐solvent ratio, and temperature. Berberine content was quantified using high‐performance thin‐layer chromatography (HPTLC). Our findings revealed that the most influential parameters in the berberine extraction process were microwave power (ranked as the most critical factor), followed by irradiation time (second in importance), and temperature (third in significance). Utilizing the dual heating approach in microwave‐assisted extraction (MAE) led to a more precise and efficient determination of extraction parameters, resulting in enhanced accuracy and higher yield. Additionally, this optimized method significantly reduced the overall extraction time, making it an ideal choice for berberine extraction under optimal conditions.
Scanes, E, Siboni, N, Potts, J, Rao, S, Labbate, M & Seymour, JR 2025, 'Temporal and spatial co-occurrence of pacific oyster mortality and increased planktonic Vibrio abundance', iScience, vol. 28, no. 2, pp. 111674-111674.
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Shen, P, Pollard, B, Ueland, M, Lawes, D & Connal, LA 2025, 'Rapid and Versatile Functionalization of Poly‐Ethylene Imine via Dynamic Aminal Formation', Macromolecular Rapid Communications, vol. 46, no. 3.
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AbstractThe study of dynamic covalent chemistry (DCC) is growing rapidly in polymer chemistry. The dynamic covalent chemistry of polyaminals formed by the reaction of linear polyethyleneimine (L‐PEI) with various functional aldehydes is explored. The study demonstrates the pH‐dependent kinetics of polyaminal formation and the versatility of polyaminals in controlling the release of aldehydes under ambient conditions. Additionally, the controlled temperature‐induced release of aldehydes and the dynamic shuffling behavior of aminals in polymer systems are investigated, emphasizing the potential for dynamic, covalently bonded polymers through dynamic aminal chemistry. The research showed the dynamic covalent aminal exchange for creating a range of new polymer materials.
Siboni, N, King, WL, Tongacan, M, Williams, NLR, Carney, R, Mahbub, KR, Rahman, MM, Seymour, JR & Labbate, M 2025, 'Antibiotic resistance gene levels within a highly urbanised estuary', Marine Environmental Research, vol. 204, pp. 106961-106961.
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Sirota, SB, Doxey, MC, Dominguez, R-MV, Bender, RG, Vongpradith, A, Albertson, SB, Novotney, A, Burkart, K, Carter, A, Abdi, P, Abdoun, M, Abebe, AM, Abegaz, KH, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Aburuz, S, Adane, MM, Addo, IY, Adekanmbi, V, Adnani, QES, Adzigbli, LA, Afzal, MS, Afzal, S, Ahinkorah, BO, Ahmad, S, Ahmed, A, Ahmed, H, Ahmed, SA, Akinosoglou, K, Akkaif, MA, Al Awaidy, S, Alalalmeh, SO, Albashtawy, M, AlBataineh, MT, Al-Gheethi, AAS, Alhalaiqa, FN, Alhassan, RK, Ali, A, Ali, L, Ali, MU, Ali, SS, Ali, W, Almazan, JU, Alqahtani, JS, Alrawashdeh, A, Al-Rifai, RH, Alshahrani, NZ, Altartoor, K, Al-Tawfiq, JA, Alvis-Guzman, N, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Al-Zyoud, WA, Amhare, AF, Amu, H, Amusa, GA, Anil, A, Anvari, S, Anyabolo, EE, Arabloo, J, Arafat, M, Areda, D, Aregawi, BB, Aremu, A, Athari, SS, Aujayeb, A, Aynalem, ZB, Azadnajafabad, S, Azzam, AY, Badar, M, Bahrami Taghanaki, P, Bahramian, S, Baig, AA, Bajcetic, M, Balakrishnan, S, Banach, M, Bardhan, M, Barqawi, HJ, Bastan, M-M, Batra, K, Batra, R, Behnoush, AH, Beiranvand, M, Belete, AG, Belete, MA, Beloukas, A, Beran, A, Bhardwaj, P, Bhargava, A, Bhat, AN, Bhuiyan, MA, Bitra, VR, Bodunrin, AO, Bogale, EK, Boppana, SH, Borhany, H, Bouaoud, S, Brown, CS, Buonsenso, D, Bustanji, Y, Cámera, LA, Castañeda-Orjuela, CA, Cegolon, L, Cenderadewi, M, Chakraborty, S, Chattu, VK, Cheng, ETW, Chichagi, F, Ching, PR, Chopra, H, Choudhari, SG, Christopher, DJ, Chu, D-T, Chukwu, IS, Chung, E, Corlateanu, A, Cruz-Martins, N, Dadana, S, Dadras, O, Dahiru, T, Dai, X, Das, JK, Dash, NR, Dashti, M, Dashtkoohi, M, De la Hoz, FP, Debopadhaya, S, Demessa, BH, Demis, AB, Devanbu, VGC, Devegowda, D, Dhama, K, Dhulipala, VR, Diaz, D, Diaz, MJ, Do, TC, Do, THP, Dodangeh, M, Dorostkar, F, Dsouza, AC, Dsouza, HL, Duraisamy, S, Durojaiye, OC, Dziedzic, AM, Ed-Dra, A, Ekholuenetale, M, Ekundayo, TC, El Sayed, I, El-Dahiyat, F, Elhadi, M, Elshaer, M, Eslami, M, Eze, UA, Fagbamigbe, AF, Faramarzi, A, Fasina, FO, Ferreira, N, Fischer, F, Fitriana, I, Flor, LS, Gaihre, S, Gajdács, M, Galehdar, N, Ganiyani, MA, Gebregergis, MW, Gebrehiwot, M, Gebremeskel, TG, Getahun, GK, Getie, M, Ghadiri, K, Ghasemzadeh, A, Ghorbani, M, Goldust, M, Golechha, M, Goleij, P, Gorini, G, Goyal, A, Guan, S-Y, Guarducci, G, Gudeta, MD, Gupta, R, Gupta, S, Gupta, VB & et al. 2025, 'Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021', The Lancet Infectious Diseases, vol. 25, no. 1, pp. 36-51.
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Smith, MB, Chou, J, Xenaki, D, Bai, X, Chen, H & Oliver, BGG 2025, 'Lunar dust induces minimal pulmonary toxicity compared to Earth dust', Life Sciences in Space Research, vol. 45, pp. 72-80.
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Solanki, N, Saini, S, Singh, SK, Paudel, KR, Goh, BH, Dua, K & Dureja, H 2025, 'Central composite designed boswellic acids loaded nanoparticles for enhanced cellular uptake in human lung cancer cell line A549', Journal of Drug Delivery Science and Technology, vol. 105, pp. 106591-106591.
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Song, Y, Zhao, H, Zi, Y, Qiu, J, Song, Z, Bai, X, Liao, J & Yang, Z 2025, 'Correction to “X-ray-Irradiation-Induced Discoloration and Persistent Radioluminescence for Reversible Dual-Mode Imaging and Detection Applications”', ACS Energy Letters, vol. 10, no. 1, pp. 68-68.
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Sun, Y, Kong, M, Ke, J, Gu, Y, Li, F & Feng, W 2025, 'Rare earth luminescent nanothermometers for biological thermal sensing', Coordination Chemistry Reviews, vol. 523, pp. 216222-216222.
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Sunstrum, FN, Khan, JU, Li, N-W & Welsh, AW 2025, 'Wearable textile sensors for continuous glucose monitoring', Biosensors and Bioelectronics, vol. 273, pp. 117133-117133.
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Tang, TW, Ritika, R, Tamtaji, M, Liu, H, Hu, Y, Liu, Z, Galligan, PR, Xu, M, Shen, J, Wang, J, You, J, Li, Y, Chen, G, Aharonovich, I & Luo, Z 2025, 'Structured-Defect Engineering of Hexagonal Boron Nitride for Identified Visible Single-Photon Emitters', ACS Nano, vol. 19, no. 9, pp. 8509-8519.
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Tarsitano, M, Liu Chung Ming, C, Bennar, L, Mahmodi, H, Wyllie, K, Idais, D, Al Shamery, W, Paolino, D, Cox, TR, Kabakova, I, Ralph, P & Gentile, C 2025, 'Chlorella-enriched hydrogels protect against myocardial damage and reactive oxygen species production in an in vitro ischemia/reperfusion model using cardiac spheroids', Biofabrication, vol. 17, no. 1, pp. 015006-015006.
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Abstract Microalgae have emerged as promising photosynthetic microorganisms for biofabricating advanced tissue constructs, with improved oxygenation and reduced reactive oxygen species (ROS) production. However, their use in the engineering of human tissues has been limited due to their intrinsic growth requirements, which are not compatible with human cells. In this study, we first formulated alginate–gelatin (AlgGel) hydrogels with increasing densities of Chlorella vulgaris. Then, we characterised their mechanical properties and pore size. Finally, we evaluated their effects on cardiac spheroid (CS) pathophysiological response under control and ischemia/reperfusion (I/R) conditions. Our results showed that the addition of Chlorella did not affect AlgGel mechanical properties, while the mean pore size significantly decreased by 35% in the presence of the 107 cells ml−1 microalgae density. Under normoxic conditions, the addition of 107 Chlorella cells ml−1 significantly reduced CS viability starting from 14 d in. No changes in pore size nor CS viability were measured for hydrogels containing 105 and 106 Chlorella cells ml−1. In our I/R model, all Chlorella-enriched hydrogels reduced cardiac cell sensitivity to hypoxic conditions with a corresponding reduction in ROS production, as well as protected against I/R-induced reduction in cell viability. Altogether, our results support a promising use of Chlorella-enriched Alg–Gel hydrogels for cardiovascular tissue engineering.
Tian, J, Song, Y, Hao, X, Wang, X, Shen, Y, Liu, P, Wei, Z, Liao, T, Jiang, L, Guo, J, Xu, B & Sun, Z 2025, 'Greatly Enhanced Oxygen Reduction Reaction in Anion Exchange Membrane Fuel Cell and Zn‐Air Battery via Hole Inner Edge Reconstruction of 2D Pd Nanomesh', Advanced Materials, vol. 37, no. 1.
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AbstractPlatinum group metals (PGM) have yet to be the most active catalysts in various sustainable energy reactions. Their high cost, however, has made maximizing the activity and minimizing the dosage become an urgent priority for the practical applications of emerging technologies. Herein, a novel 2D Pd nanomesh structure possessing hole inner reconstructed edges (HIER) with exposed high energy facets and overstretched lattice parameters is fabricated through a facile room‐temperature reduction method at gram‐scale yields. The HIER enhances the catalytic performance of Pd in electrochemical oxygen reduction reaction (ORR), achieving superior mass activity (MA) of 2.672 A mgPd−1, which is 27.8 fold and 23.6 fold higher, respectively, than those of the commercial Pt/C (0.096 A mgPt−1) and Pd/C (0.113 A mgPd−1) at 0.9 VRHE. Most significantly, in H2‐air anion exchange membrane fuel cell (AEMFC) and Zn‐air battery (ZAB) applications, this unique Pd catalyst delivers a much‐outperformed peak power density of 0.86 and 0.22 W cm−2, respectively, compared with 0.54 and 0.13 W cm−2 of the commercial Pt/C catalyst, indicating a novel pathway in electrocatalyst designs through HIER engineering.
Tobin, LA, Abu Sabah, E, Lebreton, F, Myers, GSA, McGann, PT & Hamidian, M 2025, 'Genomic analysis of early ST32 Acinetobacter baumannii strains recovered in US military treatment facilities reveals distinct lineages and links to the origins of the Tn6168 ampC transposon', Journal of Antimicrobial Chemotherapy, vol. 80, no. 3, pp. 666-675.
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Abstract Objectives To study the population structure and genomic characteristics, including antimicrobial resistance genes, plasmid types and surface polysaccharide type, of the globally distributed Acinetobacter baumannii belonging to ST32 (Institut Pasteur scheme). Methods Antibiotic resistance phenotype for 19 antibiotics was determined using Vitek 2. Whole-genome sequencing was performed using the Illumina MiSeq platform. Genomes were assembled using Newbler. Phylogenetic analysis was done by determining the core-genome alignments using Panaroo v1.3, analysed in IQ-Tree2 v2.2.0.3 to construct Maximum Likelihood trees using the RaxML software. Resistance genes and IS were identified using the Abricate programme, and ISFinder databases. Results One hundred and thirty-three (n = 133) ST32 A. baumannii isolates were analysed in this study. These genomes originated mainly from US military treatment facilities (n = 113), but also included additional publicly available genomes in GenBank (n = 20) recovered from a broad geographic distribution extending to Asia and South America. Phylogenetic analysis of all 133 genomes revealed at least four clades, with over 80 genomes forming a tightly clustered branch, suggesting they are likely to represent outbreak strains. Analysis of the ampC region showed that ST32 strains played a significant role in the formation of the widely distributed ampC transposon, Tn6168, and supplying DNA segments containing an ISAba1-ampC from ST32s via homologous recombination.
Townsend, KD 2025, 'Normalizers of Sylow subgroups in finite reflection groups', Communications in Algebra, vol. 53, no. 5, pp. 1841-1855.
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Tsoneva, DK, Buzova, D, Bianco, S, Mazza, T, Cerveny, J, Yotov, Y, Kisheva, A & Vinciguerra, M 2025, 'Circulating Histone Profiles Discriminate Heart Failure Patients With Preserved Versus Reduced Ejection Fraction', Journal of Cardiac Failure, vol. 31, no. 1, pp. 331-332.
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Vo, PHN, Kim, M, Kuzhiumparambil, U, Hinkley, C, Hong, J, Zhang, T, Pernice, M, Cullen, PJ & Ralph, PJ 2025, 'Random mutagenesis using cold atmospheric plasma to produce mutant microalgae for hyper-recovery of rare earth elements from mining materials', Chemical Engineering Journal, vol. 503, pp. 158512-158512.
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Vuori, I, Gaiani, G, Arsın, S, Delbaje, E, Järn, J, Snårbacka, R, Couëdelo, A, Murukesan, G, Wahlsten, M, Jokela, J, Shishido, TK & Fewer, DP 2025, 'Direct Evidence of Microbial Sunscreen Production by Scum‐Forming Cyanobacteria in the Baltic Sea', Environmental Microbiology Reports, vol. 17, no. 1.
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ABSTRACTMycosporine‐like amino acids are water‐soluble secondary metabolites that protect photosynthetic microorganisms from ultraviolet radiation. Here, we present direct evidence for the production of these compounds in surface scums of cyanobacteria along the Baltic Sea coast. We collected 59 environmental samples from the southern coast of Finland during the summers of 2021 and 2022 and analysed them using high‐resolution liquid chromatography‐mass spectrometry. Our results revealed the presence of microbial sunscreens in nearly all surface scum samples. Mycosporine‐like amino acids are synthesised through the coordinated action of four biosynthetic enzymes encoded in a compact biosynthetic pathway. Bioinformatics analysis of the mysB biosynthetic gene from a surface scum indicated that the cyanobacteria responsible for production belonged to the Anabaena/Dolichospermum/Aphanizomenon species complex. We mapped the distribution of biosynthetic enzymes onto a phylogenomic tree, utilising 120 bacterial single‐copy conserved genes from 101 draft or complete genomes within the species complex. This analysis showed that 48% of identified species possess the ability to produce these compounds, with biosynthetic pathways being most common in Dolichospermum and Aphanizomenon strains. We detected the production of porphyra‐334 and shinorine, two widely reported family members, in Dolichospermum strains isolated from the Gulf of Finland's surface layer. The estimated content of porphyra‐334 in Dolichospermum sp. UHCC 0684 was 7.4 mg per gram dry weight. Our results suggest that bloom‐forming cyanobacteria could be a potential source of these compounds for cosmetic and biotechnological applications and may play a significant role in cyanobacte...
Walczak, K, Piwczyński, M, Pape, T, Johnston, NP, Wallman, JF, Szpila, K & Grzywacz, A 2025, 'Unravelling phylogenetic relationships within the genus Lispe (Diptera: Muscidae) through genome-assisted and de novo analyses of RAD-seq data', Molecular Phylogenetics and Evolution, vol. 204, pp. 108291-108291.
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Wang, H, Wang, D, Jiang, H, Chen, X, Liu, X, Sun, B & Wang, Y 2025, 'Numerical simulation of lithium dendrite growth in lithium metal batteries: Effect of superimposed AC/DC electric fields on dendrites suppression', Journal of Power Sources, vol. 640, pp. 236721-236721.
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Wang, L, Wang, L, Wang, H, Dong, H, Sun, W, Lv, L, Yang, C, Xiao, Y, Wu, F, Wang, Y, Chou, S, Sun, B, Wang, G & Chen, S 2025, 'Progress and Perspective of High‐Entropy Strategy Applied in Layered Transition Metal Oxide Cathode Materials for High‐Energy and Long Cycle Life Sodium‐Ion Batteries', Advanced Functional Materials, vol. 35, no. 11.
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AbstractLayered transition metal oxide (LTMO) cathode materials of sodium‐ion batteries (SIBs) have shown great potential in large‐scale energy storage applications owing to their distinctive periodic layered structure and 2D ion diffusion channels. However, several challenges have hindered their widespread application, including phase transition complexities, interface instability, and susceptibility to air exposure. Fortunately, an impactful solution has emerged in the form of a high‐entropy doping strategy employed in energy storage research. Through the implementation of high‐entropy doping, LTMOs can overcome the aforementioned limitations, thereby elevating LTMO materials to a highly competitive and attractive option for next‐generation cathodes of SIBs. Thus, a comprehensive overview of the origins, definition, and characteristics of high‐entropy doping is provided. Additionally, the challenges associated with LTMOs in SIBs are explored, and discussed various modification methods to address these challenges. This review places significant emphasis on conducting a thorough analysis of the research advancements about high‐entropy LTMOs utilized in SIBs. Furthermore, a meticulous assessment of the future development trajectory is undertaken, heralding valuable research insights for the design and synthesis of advanced energy storage materials.
Wang, W, Mao, W, Sun, H, Hou, F, Wang, W, Liu, W, Shi, Z, Lin, G, Wang, M, Fang, G, Cheng, YY & Xu, C 2025, 'Microfluidic SERS biosensor based on Au-semicoated photonic crystals for melanoma diagnosis', Biosensors and Bioelectronics, vol. 271, pp. 116983-116983.
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Wang, Y, Bui, TA, Yang, X, Hutvagner, G & Deng, W 2025, 'Advancements in gene therapies targeting mutant KRAS in cancers', Cancer and Metastasis Reviews, vol. 44, no. 1.
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Abstract Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically, these mutations promote uncontrolled cell proliferation and alter the tumour microenvironment during early carcinoma stages. Given their critical carcinogenic functions, significant progress has been made in developing KRAS inhibitors for cancer treatment. However, clinical applications of these KRAS inhibitor compounds are limited to specific cancer types which carry the relevant KRAS mutations. Additionally, clinical findings have shown that these compounds can induce moderate to serious side effects. Therefore, new approaches have emerged focusing on the development of universal therapeutics capable of targeting a wider range of KRAS mutations, minimising toxicity and enhancing the therapeutic efficacy. This review aims to examine these therapeutic strategies in the context of cancer treatment. It firstly provides an overview of fundamental KRAS biology within the cell signalling landscape and how KRAS mutations are associated with cancer pathogenesis. Subsequently, it introduces the development of current KRAS inhibitors which target certain KRAS mutants in different types of cancer. It then explores the potential of gene therapy approaches, including siRNA, miRNA and CRISPR methodologies. Furthermore, it discusses the use of lipid-based nanocarriers to deliver gene cargos for targeting KRAS gene mutants. Finally, it provides the insights into the future prospects for combatting KRAS mutation-associated cancers. Graphical Abstract
Watson, JL, Cho, K, Grisedale, K, Ward, J & McNevin, D 2025, 'Characterisation of identity-informative genetic markers in the Australian population with European ancestry', Forensic Science International: Genetics, vol. 74, pp. 103169-103169.
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Webb, JR, Andersson, P, Sim, E, Zahedi, A, Donald, A, Hoang, T, Watt, AE, Agius, JE, Donato, CM, Cummins, ML, Zulfiqar, T, Nghiem, S, Lin, C, Menouhos, D, Leong, LEX, Baird, R, Kennedy, K, Cooley, L, Speers, D, Lim, CK, de Ligt, J, Ferdinand, A, Glass, K, Kirk, MD, Djordjevic, SP, Sloggett, C, Horan, K, Seemann, T, Sintchenko, V, Jennison, AV & Howden, BP 2025, 'Implementing a national programme of pathogen genomics for public health: the Australian Pathogen Genomics Program (AusPathoGen)', The Lancet Microbe, vol. 6, no. 3, pp. 100969-100969.
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Williams, NLR, Siboni, N, Potts, J, Scanes, P, Johnson, C, James, M, McCann, V, Reun, NL, King, WL & Seymour, JR 2025, 'Faecal contamination determines bacterial assemblages over natural environmental parameters within intermittently opened and closed lagoons (ICOLLs) during high rainfall', Water Research, vol. 268, pp. 122670-122670.
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Wu, HHL, Bhagavath, V, Nguyen, LT, Chinnadurai, R, Goldys, EM, Pollock, CA & Saad, S 2025, 'Association Between Glycemic Control and Complications With Concentration of Urinary Exfoliated Proximal Tubule Kidney Cells in People With Diabetes Mellitus', Journal of Diabetes Research, vol. 2025, no. 1.
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Background: Emerging evidence suggests cell exfoliation could be operating under the control of cell metabolism. It is unclear if there are associations between the concentration of exfoliated kidney proximal tubule cells (PTCs) in urine with glycemic control and complications. Our study is aimed at exploring this.Methods: Urine samples were collected from 122 adult study participants and stored at −80°C. Exfoliated PTCs were extracted from thawed urine using a validated specific immunomagnetic separation method based on anti‐CD13 and anti‐SGLT‐2 antibodies. The number of PTCs was assessed using brightfield microscopy. Study participants were grouped into those with no diabetes mellitus (DM) and those with DM. Individuals with DM were further subgrouped into those with and without retinopathy. Adjusted Poisson regression analysis was conducted for the DM cohort, investigating associations between demographic, clinical, and biochemical parameters with mean urinary exfoliated PTCs.Results: The adjusted Poisson regression analysis noted sex to have a significant association with mean number of urinary exfoliated PTCs, with a lower incidence rate in males compared to females (incidence rate ratio (IRR) 0.56, 95% CI 0.35–0.89, p = 0.014). Each 1% increase in glycated haemoglobin (HbA1c) was associated with an increase of 1.03 times in mean exfoliated PTCs (IRR 1.03, 95% CI 1.01–1.04, p = 0.007), and DM patients with retinopathy had an increase of 1.68 times in mean exfoliated PTCs compared to those without retinopathy (IRR 1.68, 95% CI 1.07–2.62, p = 0.024). No significant associations were observed with albuminuria or estimated glomerular filtration rate (eGFR).Conclusions: Our results indicate increased shedding of PTCs into the...
Wu, X, Lim, CED, Zheng, S & Zaslawski, C 2025, 'Effects of Needling Acupoint SI3 on Pressure Pain Threshold in Healthy Participants', Perspectives on Integrative Medicine, vol. 4, no. 1, pp. 39-50.
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Background: There has been a surge in prescribing opioids for pain-related conditions and it has resulted in a prescription 'opioid epidemic.' It is critical for researchers and clinicians to explore nonpharmacological approaches to manage pain and mitigate the reliance on opioid analgesics. Acupuncture could be an effective therapy to modulate pain. This study examined the effects on regional pressure pain threshold (PPT) following needling of the Small Intestine 3 (SI3 -Houxi) acupoint in healthy participants.Methods: In a randomized, three-arm cross-over design study, 32 healthy participants enrolled between November 2018 and March 2019, received 3 different acupuncture interventions, in different sequences, to the right hand at SI3: (1) SI3 without manual manipulation (SI3m-); (2) SI3 with manual needle manipulation (SI3m+); and (3) sham laser, to assess changes in PPT following the interventions. The mean change in PPT was measured at 10 different regional acupoint sites using an algometer. All PPT scores were reported as a percentage change from the mean preintervention value, the mean of the 3 PPT measurements obtained prior to receiving the intervention.Results: The SI3m+ and SI3m- interventions for the 31 participants (drop out <i>n</i>=1), showed that the postintervention mean % PPT scores were significantly elevated compared to the control (sham laser; <i>p</i> < 0.001). The SI3m+ intervention significantly increased % PPT compared with the SI3m- intervention (<i>p</i> < 0.001).Conclusion: The needling intervention was an important contributor raising regional PPT in healthy participants.
Xiang, K, Wang, B, Liu, DL, Chen, C, Ji, F, Yang, Y, Li, S, Huang, M, Huete, A & Yu, Q 2025, 'Soil with high plant available water capacity can mitigate the risk of wheat growth under drought conditions in southeastern Australia', European Journal of Agronomy, vol. 164, pp. 127460-127460.
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Xiao, J, Gao, H, Xiao, Y, Wang, S, Gong, C, Huang, Z, Sun, B, Dong, C-L, Guo, X, Liu, H & Wang, G 2025, 'A hydro-stable and phase-transition-free P2-type cathode with superior cycling stability for high-voltage sodium-ion batteries', Chemical Engineering Journal, vol. 506, pp. 160010-160010.
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Yamamura, K, An, S, Zhigulin, I, Kianinia, M, Wu, Y, Dong, Z & Aharonovich, I 2025, 'Toward Emission Enhancement of Blue Emitters in hBN Using Plasmonic Lattices', ACS Applied Optical Materials, vol. 3, no. 1, pp. 64-69.
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Yang, Y, Chen, H, Huang, S, Chen, H, Verkhratsky, A, Niu, J, Qu, Y & Yi, C 2025, 'BOK-engaged mitophagy alleviates neuropathology in Alzheimer’s disease', Brain, vol. 148, no. 2, pp. 432-447.
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Abstract Mitochondrial malfunction associated with impaired mitochondrial quality control and self-renewal machinery, known as mitophagy, is an under-appreciated mechanism precipitating synaptic loss and cognitive impairments in Alzheimer’s disease. Promoting mitophagy has been shown to improve cognitive function in Alzheimer’s disease animals. However, the regulatory mechanism was unclear, which formed the aim of this study. Here, we found that a neuron-specific loss of Bcl-2 family member BOK in patients with Alzheimer’s disease and APPswe/PS1dE9 (APP/PS1) mice is closely associated with mitochondrial damage and mitophagy defects. We further revealed that BOK is the key to the Parkin-mediated mitophagy through competitive binding to the MCL1/Parkin complex, resulting in Parkin release and translocation to damaged mitochondria to initiate mitophagy. Furthermore, overexpressing bok in hippocampal neurons of APP/PS1 mice alleviated mitophagy and mitochondrial malfunction, resulting in improved cognitive function. Conversely, the knockdown of bok worsened the aforementioned Alzheimer’s disease-related changes. Our findings uncover a novel mechanism of BOK signalling through regulating Parkin-mediated mitophagy to mitigate amyloid pathology, mitochondrial and synaptic malfunctions, and cognitive decline in Alzheimer’s disease, thus representing a promising therapeutic target.
Yang, Y, Jeon, Y, Dong, Z, Yang, JKW, Haddadi Moghaddam, M, Kim, D-S, Oh, DK, Lee, J, Hentschel, M, Giessen, H, Kang, D, Kim, G, Tanaka, T, Zhao, Y, Bürger, J, Maier, SA, Ren, H, Jung, W, Choi, M, Bae, G, Chen, H, Jeon, S, Kim, J, Lee, E, Kang, H, Park, Y, Du Nguyen, D, Kim, I, Cencillo-Abad, P, Chanda, D, Jing, X, Liu, N, Martynenko, IV, Liedl, T, Kwak, Y, Nam, J-M, Park, S-M, Odom, TW, Lee, H-E, Kim, RM, Nam, KT, Kwon, H, Jeong, H-H, Fischer, P, Yoon, J, Kim, S-H, Shim, S, Lee, D, Pérez, LA, Qi, X, Mihi, A, Keum, H, Shim, M, Kim, S, Jang, H, Jung, YS, Rossner, C, König, TAF, Fery, A, Li, Z, Aydin, K, Mirkin, CA, Seong, J, Jeon, N, Xu, Z, Gu, T, Hu, J, Kwon, H, Jung, H, Alijani, H, Aharonovich, I, Kim, J & Rho, J 2025, 'Nanofabrication for Nanophotonics.', ACS Nano.
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Nanofabrication, a pivotal technology at the intersection of nanoscale engineering and high-resolution patterning, has substantially advanced over recent decades. This technology enables the creation of nanopatterns on substrates crucial for developing nanophotonic devices and other applications in diverse fields including electronics and biosciences. Here, this mega-review comprehensively explores various facets of nanofabrication focusing on its application in nanophotonics. It delves into high-resolution techniques like focused ion beam and electron beam lithography, methods for 3D complex structure fabrication, scalable manufacturing approaches, and material compatibility considerations. Special attention is given to emerging trends such as the utilization of two-photon lithography for 3D structures and advanced materials like phase change substances and 2D materials with excitonic properties. By highlighting these advancements, the review aims to provide insights into the ongoing evolution of nanofabrication, encouraging further research and application in creating functional nanostructures. This work encapsulates critical developments and future perspectives, offering a detailed narrative on the state-of-the-art in nanofabrication tailored for both new researchers and seasoned experts in the field.
Yu, XF, Lim, CED & Chen, H 2025, 'The role of vitamin D in glycaemic control in patients with type 2 diabetes—A pilot D4D trial', Diabetes, Obesity and Metabolism, vol. 27, no. 1, pp. 428-431.
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Zaarour, L, Padula, M, van Oorschot, RAH & McNevin, D 2025, 'Mass spectrometry-based proteomics for source-level attribution after DNA extraction', Forensic Science International: Genetics, vol. 74, pp. 103168-103168.
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Zhand, S, Goss, DM, Cheng, YY & Warkiani, ME 2025, 'Recent Advances in Microfluidics for Nucleic Acid Analysis of Small Extracellular Vesicles in Cancer', Advanced Healthcare Materials, vol. 14, no. 4.
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AbstractSmall extracellular vesicles (sEVs) are membranous vesicles released from cellular structures through plasma membrane budding. These vesicles contain cellular components such as proteins, lipids, mRNAs, microRNAs, long‐noncoding RNA, circular RNA, and double‐stranded DNA, originating from the cells they are shed from. Ranging in size from ≈25 to 300 nm and play critical roles in facilitating cell‐to‐cell communication by transporting signaling molecules. The discovery of sEVs in bodily fluids and their involvement in intercellular communication has revolutionized the fields of diagnosis, prognosis, and treatment, particularly in diseases like cancer. Conventional methods for isolating and analyzing sEVs, particularly their nucleic acid content face challenges including high costs, low purity, time‐consuming processes, limited standardization, and inconsistent yield. The development of microfluidic devices, enables improved precision in sorting, isolating, and molecular‐level separation using small sample volumes, and offers significant potential for the enhanced detection and monitoring of sEVs associated with cancer. These advanced techniques hold great promise for creating next‐generation diagnostic and prognostic tools given their possibility of being cost‐effective, simple to operate, etc. This comprehensive review explores the current state of research on microfluidic devices for the detection of sEV‐derived nucleic acids as biomarkers and their translation into practical point‐of‐care and clinical applications.
Zhao, H, Liao, J, Fu, S, Zi, Y, Bai, X, Ci, Y, Zhang, Y, Cai, X, Li, Y, Cun, Y, Huang, A, Liu, Y, Qiu, J, Song, Z, Li, G, Zhou, J & Yang, Z 2025, 'Direct 3D Lithography of Reversible Photochromic Patterns with Tunable Luminescence in Amorphous Transparent Media', ACS Energy Letters, vol. 10, no. 3, pp. 1235-1244.
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Zheng, K, Gao, X, Xie, Y, He, Z, Ma, Y, Hou, S, Su, D & Ma, X 2025, 'Free-standing bimetallic Co/Ni-MOF foams toward enhanced methane dry reforming under non-thermal plasma catalysis', Journal of Colloid and Interface Science, vol. 683, pp. 564-573.
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Zhou, C, Ding, Z, Ying, S, Jiang, H, Wang, Y, Fang, T, Zhang, Y, Sun, B, Tang, X & Liu, X 2025, 'Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries', Nano-Micro Letters, vol. 17, no. 1.
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AbstractAqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.
Zhu, Q, Yang, X, Ji, F & Du, Z 2025, 'Rainfall Erosivity Projection in South‐East Australia Using the Improved Regional Climate Simulations', International Journal of Climatology, vol. 45, no. 2.
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ABSTRACTRainfall erosivity is one of the most dynamic factors in the soil erosion process. The increase in soil erosion caused by high rainfall erosivity, and the subsequent loss of soil nutrients, can lead to reduced food production and ecosystem services. This research program under the New South Wales (NSW) Climate Change Adaptation Strategy, assesses rainfall pattern change, rainfall erosivity and erosion risk across NSW under future climate conditions. Daily rainfall erosivity and erosion risk were modelled by Revised Soil Loss Universal Equation (RUSLE) approach and compared with that driven by observed rainfall data. Future rainfall erosivity and soil erosion risk change were investigated from daily precipitation projection of the updated NSW and Australian Regional Climate Modelling (NARCliM1.5) for two future scenarios, RCP4.5 and RCP8.5, from the historical (1986–2005) to far future (2060–2079) periods. The annual average rainfall erosivity is projected to increase about 8% under RCP 4.5 and further decrease 5% under RCP 8.5 in NSW due to the predicted temperature rises. More frequent heavy rainfall events are projected to occur during summer (December–January–February), and the rainfall from these extreme rainfall events is expected to account for 51% of the total annual rainfall in the far future. NARCliM‐derived results underestimate annual rainfall erosivity compared with observation‐derived erosivity. There are greater instability (root mean squared error [RMSE]: 803.2) and erosivity uncertainty (Bias: 16%~48%) in high rainfall zones. At a monthly scale, dry months (June–July–August) are becoming drier, while wet months (December–January–February) are becoming wetter and more erosive. 67% of NSW is predicted to experience increased rainfall erosivity under RCP4.5, whereas most of NSW will shift to drought and its consequent effects under the high‐end emission scenario (RCP 8.5). To address the dual challen...
Zhu, Y, Verkhratsky, A, Chen, H & Yi, C 2025, 'Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases', Acta Physiologica, vol. 241, no. 2.
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AbstractThe blood–brain barrier (BBB) is a highly selective, semipermeable barrier critical for maintaining brain homeostasis. The BBB regulates the transport of essential nutrients, hormones, and signaling molecules between the bloodstream and the central nervous system (CNS), while simultaneously protecting the brain from potentially harmful substances and pathogens. This selective permeability ensures that the brain is nourished and shielded from toxins. An exception to this are brain regions, such as the hypothalamus and circumventricular organs, which are irrigated by fenestrated capillaries, allowing rapid and direct response to various blood components. We overview the metabolic functions of the BBB, with an emphasis on the impact of altered glucose metabolism and insulin signaling on BBB in the pathogenesis of neurodegenerative diseases. Notably, endothelial cells constituting the BBB exhibit distinct metabolic characteristics, primarily generating ATP through aerobic glycolysis. This occurs despite their direct exposure to the abundant oxygen in the bloodstream, which typically supports oxidative phosphorylation. The effects of insulin on astrocytes, which form the glial limitans component of the BBB, show a marked sexual dimorphism. BBB nutrient sensing in the hypothalamus, along with insulin signaling, regulates systemic metabolism. Insulin modifies BBB permeability by regulating the expression of tight junction proteins, angiogenesis, and vascular remodeling, as well as modulating blood flow in the brain. The disruptions in glucose and insulin signaling are particularly evident in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where BBB breakdown accelerates cognitive decline. This review highlights the critical role of normal glucose metabolism and insulin signaling in maintaining BBB functionality and investigates how disruptions in these pathways contribute to the onset an...
Zieger, M & Scudder, N 2025, 'Ethical and legal reflections on secondary research using genetic data acquired for criminal investigation purposes', Forensic Science International: Genetics, vol. 75, pp. 103178-103178.
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Zou, Y, Chen, W, Li, S, Wang, T, Yu, L, Zhang, X, Xu, M, Jiang, B, Wu, C, Singh, RP, Huete, A & Liu, C-Q 2025, 'Assessing vegetation dynamics and human impacts in natural and urban areas of China: Insights from remote sensing data', Journal of Environmental Management, vol. 373, pp. 123632-123632.
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